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Literature summary extracted from

  • Zhang, J.L.; Zheng, Q.C.; Li, Z.Q.; Zhang, H.X.
    Molecular dynamics simulations suggest ligands binding to nicotinamidase/pyrazinamidase (2012), PLoS ONE, 7, e39546.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.5.1.B15 crystal structure (PDB ID 2WT9) analysis, and modeling of substrate binding and unbinding, overview Acinetobacter baumannii
3.5.1.19 crystal structure (PDB ID 2WT9) analysis, and modeling of substrate binding and unbinding, overview Acinetobacter baumannii
3.5.1.19 crystal structure (PDB ID 3O94) analysis, and modeling of substrate binding and unbinding, overview Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.B15 nicotinamide + H2O Acinetobacter baumannii
-
 nicotinate + NH3
-
 ?
3.5.1.B15 pyrazinamide + H2O Acinetobacter baumannii
-
 pyrazinoic acid + NH3
-
 ?
3.5.1.19 nicotinamide + H2O Streptococcus pneumoniae
-
 nicotinate + NH3
-
 ?
3.5.1.19 nicotinamide + H2O Acinetobacter baumannii
-
 nicotinate + NH3
-
 ?
3.5.1.19 pyrazinamide + H2O Streptococcus pneumoniae
-
 pyrazinoic acid + NH3
-
 ?
3.5.1.19 pyrazinamide + H2O Acinetobacter baumannii
-
 pyrazinoic acid + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.B15 Acinetobacter baumannii B0VA03 gene pncA
-
3.5.1.19 Acinetobacter baumannii B0VA03 gene pncA
-
3.5.1.19 Streptococcus pneumoniae A0A0H2UR34
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.B15 nicotinamide + H2O
-
 Acinetobacter baumannii nicotinate + NH3
-
 ?
3.5.1.B15 nicotinamide + H2O binding structure involving residues A155, C159, and Ile154, and unbinding mechanism, modeling, overview Acinetobacter baumannii nicotinate + NH3
-
 ?
3.5.1.B15 pyrazinamide + H2O
-
 Acinetobacter baumannii pyrazinoic acid + NH3
-
 ?
3.5.1.19 nicotinamide + H2O
-
 Streptococcus pneumoniae nicotinate + NH3
-
 ?
3.5.1.19 nicotinamide + H2O
-
 Acinetobacter baumannii nicotinate + NH3
-
 ?
3.5.1.19 nicotinamide + H2O binding structure and unbinding mechanism, modeling, overview Streptococcus pneumoniae nicotinate + NH3
-
 ?
3.5.1.19 nicotinamide + H2O binding structure involving residues A155, C159, and Ile154, and unbinding mechanism, modeling, overview Acinetobacter baumannii nicotinate + NH3
-
 ?
3.5.1.19 pyrazinamide + H2O
-
 Streptococcus pneumoniae pyrazinoic acid + NH3
-
 ?
3.5.1.19 pyrazinamide + H2O
-
 Acinetobacter baumannii pyrazinoic acid + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.B15 More cf. EC 3.5.1.19 Acinetobacter baumannii
3.5.1.B15 nicotinamidase/pyrazinamidase
-
 Acinetobacter baumannii
3.5.1.B15 PncA
-
 Acinetobacter baumannii
3.5.1.B15 pyrazinamidase
-
 Acinetobacter baumannii
3.5.1.B15 PZAse
-
 Acinetobacter baumannii
3.5.1.19 nicotinamidase/pyrazinamidase
-
 Acinetobacter baumannii
3.5.1.19 PncA
-
 Acinetobacter baumannii
3.5.1.19 pyrazinamidase
-
 Acinetobacter baumannii
3.5.1.19 PZAse
-
 Acinetobacter baumannii

General Information

EC Number General Information Comment Organism
3.5.1.B15 additional information protein conformational changes after ligand dissociation, molecular dynamics simulation methods are performed to investigate the unbinding process of nicotinamide using the enzyme's crystal structure. PDB ID 2WT9 Acinetobacter baumannii
3.5.1.19 additional information protein conformational changes after ligand dissociation, molecular dynamics simulation methods are performed to investigate the unbinding process of nicotinamide using the enzyme's crystal structure, PDB ID 3O94, the C136S mutation in 3O94 is restored to the wild-type Cys residue Streptococcus pneumoniae
3.5.1.19 additional information protein conformational changes after ligand dissociation, molecular dynamics simulation methods are performed to investigate the unbinding process of nicotinamide using the enzyme's crystal structure. PDB ID 2WT9 Acinetobacter baumannii