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Literature summary extracted from

  • Zhou, X.-R.; Robert S.; Singh, S.; Green, A.
    Heterologous production of GLA and SDA by expression of an Echium plantagineum DELTA6-desaturase gene (2007), Plant Sci., 172, 421-422.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.47 expressed in Nicotiana tabacum leaf and Arabidopsis thaliana seed Echium plantagineum

Protein Variants

EC Number Protein Variants Comment Organism
1.14.19.47 D169V/T275A the mutant has little effect on the D6-desaturation activity of the enzyme Echium plantagineum
1.14.19.47 L14P the mutant shows dramatically reduced activity compared to the wild type enzyme Echium plantagineum
1.14.19.47 L224S the mutant shows dramatically reduced activity compared to the wild type enzyme Echium plantagineum
1.14.19.47 L371F the mutant shows dramatically reduced activity compared to the wild type enzyme Echium plantagineum
1.14.19.47 S205N the mutant has little effect on the D6-desaturation activity of the enzyme Echium plantagineum
1.14.19.47 S301P the mutant shows dramatically reduced activity compared to the wild type enzyme Echium plantagineum
1.14.19.47 S391P the mutant shows dramatically reduced activity compared to the wild type enzyme Echium plantagineum
1.14.19.47 V137A the mutant shows dramatically reduced activity compared to the wild type enzyme Echium plantagineum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.47 alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ Echium plantagineum
-
 stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?
1.14.19.47 linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ Echium plantagineum preferred substrate gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.47 Echium plantagineum Q2M488
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.47 alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
-
 Echium plantagineum stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?
1.14.19.47 linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ preferred substrate Echium plantagineum gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.47 D6Des
-
 Echium plantagineum
1.14.19.47 DELTA6-desaturase
-
 Echium plantagineum

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.47 cytochrome b5
-
 Echium plantagineum