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Literature summary extracted from

  • Campos, M.C.; Castro-Pinto, D.B.; Ribeiro, G.A.; Berredo-Pinho, M.M.; Gomes, L.H.; da Silva Bellieny, M.S.; Goulart, C.M.; Echevarria, A.; Leon, L.L.
    P-glycoprotein efflux pump plays an important role in Trypanosoma cruzi drug resistance (2013), Parasitol. Res., 112, 2341-2351.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 cyclosporin A
-
 Trypanosoma cruzi
7.6.2.2 orthovanadate
-
 Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 membrane
-
 Trypanosoma cruzi 16020
-

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Trypanosoma cruzi
-
-
-
7.6.2.2 Trypanosoma cruzi Y
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 amastigote
-
 Trypanosoma cruzi
-
7.6.2.2 epimastigote
-
 Trypanosoma cruzi
-
7.6.2.2 trypomastigote
-
 Trypanosoma cruzi
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + 4-N-(2'-methoxystyryl)-thiosemicarbazone/in
-
 Trypanosoma cruzi ADP + phosphate + 4-N-(2'-methoxystyryl)-thiosemicarbazone/out
-
 ?
7.6.2.2 ATP + H2O + 4-N-(2'-methoxystyryl)-thiosemicarbazone/in
-
 Trypanosoma cruzi Y ADP + phosphate + 4-N-(2'-methoxystyryl)-thiosemicarbazone/out
-
 ?
7.6.2.2 ATP + H2O + N-benzyl-2-nitro-1H-imidazole-1-acetamide/in
-
 Trypanosoma cruzi ADP + phosphate + N-benzyl-2-nitro-1H-imidazole-1-acetamide/out
-
 ?
7.6.2.2 ATP + H2O + N-benzyl-2-nitro-1H-imidazole-1-acetamide/in
-
 Trypanosoma cruzi Y ADP + phosphate + N-benzyl-2-nitro-1H-imidazole-1-acetamide/out
-
 ?
7.6.2.2 ATP + H2O + rhodamine 123/in
-
 Trypanosoma cruzi ADP + phosphate + rhodamine 123/out
-
 ?
7.6.2.2 ATP + H2O + rhodamine 123/in
-
 Trypanosoma cruzi Y ADP + phosphate + rhodamine 123/out
-
 ?
7.6.2.2 ATP + H2O + verapamil/in
-
 Trypanosoma cruzi ADP + phosphate + verapamil/out
-
 ?
7.6.2.2 ATP + H2O + verapamil/in
-
 Trypanosoma cruzi Y ADP + phosphate + verapamil/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 P-glycoprotein
-
 Trypanosoma cruzi
7.6.2.2 Pgp
-
 Trypanosoma cruzi
7.6.2.2 PGP1 isoform Trypanosoma cruzi
7.6.2.2 Pgp2 isoform Trypanosoma cruzi

General Information

EC Number General Information Comment Organism
7.6.2.2 physiological function the enzyme participates in drug resistance Trypanosoma cruzi