EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | actinomycin D | 1 mM increases the ATPase activity of the enzyme more than 5times | Caenorhabditis elegans | |
7.6.2.2 | dipyridamole | 1 mM increases the ATPase activity of the enzyme more than 5times | Caenorhabditis elegans | |
7.6.2.2 | paclitaxel | 1 mM increases the ATPase activity of the enzyme more than 5times | Caenorhabditis elegans | |
7.6.2.2 | progesterone | 1 mM increases the ATPase activity of the enzyme more than 5times | Caenorhabditis elegans | |
7.6.2.2 | valinomycin | 1 mM increases the ATPase activity of the enzyme more than 5times | Caenorhabditis elegans |
EC Number | Cloned (Comment) | Organism |
---|---|---|
7.6.2.2 | native protein is expressed in Pichia pastoris strain SMD1163 and Sf9 insect cells, while selenomethionine-labeled protein is expressed in Hi5 cells | Caenorhabditis elegans |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
7.6.2.2 | sitting drop vapor diffusion method, native protein is crystallized by using 100 mM HEPES pH 6.6-7.2, 200 mM sodium malonate and 19-22% (w/v) PEG 2000-MME, at 4°C. Crystals of selenomethionine-substituted protein are obtained with 100 mM HEPES pH 6.6-7.2, 200 mM ammonium phosphate monobasic and 19-22% PEG 1500 at 4°C | Caenorhabditis elegans |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | vanadate | complete inhibition at 1 mM | Caenorhabditis elegans |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
7.6.2.2 | membrane | - |
Caenorhabditis elegans | 16020 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.6.2.2 | Caenorhabditis elegans | P34712 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
7.6.2.2 | cobalt affinity resin column chromatography, GST column chromatography, and Superdex 200 gel filtration | Caenorhabditis elegans |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | ATP + H2O + actinomycin D/in | - |
Caenorhabditis elegans | ADP + phosphate + actinomycin D/out | - |
? | |
7.6.2.2 | ATP + H2O + paclitaxel/in | - |
Caenorhabditis elegans | ADP + phosphate + paclitaxel/out | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
7.6.2.2 | P-glycoprotein | - |
Caenorhabditis elegans |
7.6.2.2 | P-gp | - |
Caenorhabditis elegans |