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Literature summary extracted from

  • Causeret, C.; Geeraert, L.; Van der Hoeven, G.; Mannaerts, G.; Van Veldhoven, P.
    Further characterization of rat dihydroceramide desaturase: Tissue distribution, subcellular localization, and substrate specificity (2000), Lipids, 35, 1117-1125.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.19.17 albumin
-
Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.17 alpha-cyclodextrin 18% residual activity at a substrate/cyclodextrin molar ratio of 0.5 Rattus norvegicus
1.14.19.17 beta-cyclodextrin 20% residual activity at a substrate/cyclodextrin molar ratio of 0.5 Rattus norvegicus
1.14.19.17 Brij-35 13% residual activity at 0.1 mM Rattus norvegicus
1.14.19.17 CHAPS 3.0% residual activity at 6.5 mM Rattus norvegicus
1.14.19.17 decylmaltoside 27% residual activity at 1.6 mM Rattus norvegicus
1.14.19.17 lauryl-N,N-dimethylamine 28% residual activity at 2.1 mM Rattus norvegicus
1.14.19.17 N-dodecylsarcosine complete inhibition at 14.6 mM Rattus norvegicus
1.14.19.17 N-octyl-N,N-dimethyl-3-ammonio-1-propane sulfonate 18% residual activity at 330 mM Rattus norvegicus
1.14.19.17 octylglucoside 8.5% residual activity at 25 mM Rattus norvegicus
1.14.19.17 SDS 0.3% residual activity at 0.24% (w/v) Rattus norvegicus
1.14.19.17 sucrose monolaurate 27% residual activity at 0.2 mM Rattus norvegicus
1.14.19.17 Thesit 23% residual activity at 0.1 mM Rattus norvegicus
1.14.19.17 Triton X-100 13% residual activity at 0.25 mM Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.17 endoplasmic reticulum
-
Rattus norvegicus 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.17 dihydroceramide + ferrocytochrome b5 + O2 + H+ Rattus norvegicus
-
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.17 Rattus norvegicus Q564G3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.17 harderian gland
-
Rattus norvegicus
-
1.14.19.17 hepatocyte
-
Rattus norvegicus
-
1.14.19.17 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.17 dihydroceramide + ferrocytochrome b5 + O2 + H+
-
Rattus norvegicus (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
?
1.14.19.17 N-hexanoyl-[4,5-3H]sphinganine + NADPH + O2 + H+
-
Rattus norvegicus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.17 DHCD
-
Rattus norvegicus
1.14.19.17 dihydroceramide desaturase
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.17 cytochrome b5
-
Rattus norvegicus
1.14.19.17 NADH dependent on, higher activity with NADPH compared to NADH Rattus norvegicus
1.14.19.17 NADPH dependent on, higher activity with NADPH compared to NADH Rattus norvegicus