Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Yoshimoto, F.K.; Auchus, R.J.
    The diverse chemistry of cytochrome P450 17A1 (P450c17, CYP17A1) (2015), J. Steroid Biochem. Mol. Biol., 151, 52-65.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.32 17-hydroxy-5alpha-pregnan-3alpha-ol-20-one + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 androsterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.32 17alpha-hydroxy-5alpha-dihydroprogesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 5alpha-androstanedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.32 5alpha-dihydroprogesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 17alpha-hydroxy-5alpha-dihydroprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.32 5alpha-pregnan-3alpha-ol-20-one + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 17-hydroxy-5alpha-pregnan-3alpha-ol-20-one + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.32 pregnenolone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.32 progesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.32 Homo sapiens P05093
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.32 adrenal gland
-
 Homo sapiens
-
1.14.14.32 brain
-
 Homo sapiens
-
1.14.14.32 gonad
-
 Homo sapiens
-
1.14.14.32 heart
-
 Homo sapiens
-
1.14.14.32 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.32 17-hydroxy-5alpha-pregnan-3alpha-ol-20-one + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens androsterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.32 17alpha-hydroxy-5alpha-dihydroprogesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 5alpha-androstanedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.32 5alpha-dihydroprogesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 17alpha-hydroxy-5alpha-dihydroprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.32 5alpha-pregnan-3alpha-ol-20-one + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 17-hydroxy-5alpha-pregnan-3alpha-ol-20-one + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.32 additional information the enzyme shows also about 20% 16alpha-hydroxylase activity and some 21alpha-hydroxylase activity with progesterone Homo sapiens ?
-
 ?
1.14.14.32 pregnenolone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.32 progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.32 17alpha-hydroxylase
-
 Homo sapiens
1.14.14.32 CYP17A1
-
 Homo sapiens
1.14.14.32 cytochrome P450 17A1
-
 Homo sapiens
1.14.14.32 P450c17
-
 Homo sapiens