Literature summary extracted from

Zhu, Z.; Yang, F.; Zhang, K.; Cao, W.; Jin, Y.; Wang, G.; Mao, R.; Li, D.; Guo, J.; Liu, X.; Zheng, H.
Comparative proteomic analysis of wild-type and SAP domain-mutant Foot-and-mouth disease virus (FMDV)-infected porcine cells identifies the ubiquitin-activating enzyme UBE1 required for virus replication (2015), J. Proteome Res., 14, 4194-4206.

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.2.1.45	Sus scrofa	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
6.2.1.45	SK6 cell	-	Sus scrofa	-

Synonyms

EC Number	Synonyms	Comment	Organism
6.2.1.45	UBE1	-	Sus scrofa
6.2.1.45	Ubiquitin-activating enzyme	-	Sus scrofa

General Information

EC Number	General Information	Comment	Organism
6.2.1.45	physiological function	comparative proteomic analysis of wild-type and SAP domain-mutant Foot-and-mouth disease virus-infected porcine cells identifies the ubiquitin-activating enzyme UBE1 required for virus replication. Overexpression of the enzyme UBE1 enhances the replication of the virus, and knockdown of UBE1 decreases virus replication. te virus manipulates UBE1 for increased viral replication, and the SAP domain is involved in this process, overview	Sus scrofa

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Release 2023.1 (January 2023)