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Literature summary extracted from

  • Guo, L.; Zhang, X.; Zhou, D.; Okunade, A.; Su, X.
    Stereospecificity of fatty acid 2-hydroxylase and differential functions of 2-hydroxy fatty acid enantiomers (2012), J. Lipid Res., 53, 1327-1335.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.18.6 expression in CHO cell Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.6 Homo sapiens Q7L5A8
-
-
1.14.18.6 Mus musculus Q5MPP0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.6 3T3-L1 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.6 additional information FA2H is stereospecific for the production of (R)-enantiomers Mus musculus ?
-
 ?
1.14.18.6 additional information initiates fatty acid alpha-oxidation and is also responsible for the biosynthesis of 2-hydroxy fatty acid-containing sphingolipids in mammalian cells Homo sapiens ?
-
 ?
1.14.18.6 palmitic acid + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Homo sapiens (R)-2-hydroxypalmitic acid + 2 ferricytochrome b5 + H2O FA2H is stereospecific for the production of (R)-enantiomers ?

General Information

EC Number General Information Comment Organism
1.14.18.6 physiological function FA2H knockdown in adipocytes increases diffusional mobility of raft-associated lipids, leading to reduced GLUT4 protein level, glucose uptake, and lipogenesis Mus musculus