Literature summary extracted from

Petrovic, V.; Colovic, M.; Krstic, D.; Vujacic, A.; Petrovic, S.; Joksic, G.; Bugarcic, A.; Vasic, V.
In vitro effects of some gold complexes on Na+/K+ ATPase activity and cell proliferation (2013), J. Inorg. Biochem., 124, 35-41.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
7.2.2.13	AuCl4-	-	Sus scrofa
7.2.2.13	[Au(2,2'-bipyridine)Cl2]+	-	Sus scrofa
7.2.2.13	[Au(dimethylsulfoxide)2Cl2]+	-	Sus scrofa

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
7.2.2.13	membrane	-	Sus scrofa	16020	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
7.2.2.13	ATP + H2O + Na+/in + K+/out	Sus scrofa	-	ADP + phosphate + Na+/out + K+/in	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
7.2.2.13	Sus scrofa	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
7.2.2.13	brain cortex	-	Sus scrofa	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7.2.2.13	ATP + H2O + Na+/in + K+/out	-	Sus scrofa	ADP + phosphate + Na+/out + K+/in	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
7.2.2.13	Na+,K+-ATPase	-	Sus scrofa
7.2.2.13	sodium potassium adenosinetriphosphatase	-	Sus scrofa

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
7.2.2.13	0.000575	-	at pH 7.4 and 37°C	Sus scrofa	AuCl4-
7.2.2.13	0.0055	-	at pH 7.4 and 37°C	Sus scrofa	[Au(dimethylsulfoxide)2Cl2]+
7.2.2.13	0.0398	-	at pH 7.4 and 37°C	Sus scrofa	[Au(2,2'-bipyridine)Cl2]+

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Release 2023.1 (January 2023)