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Literature summary extracted from

  • Joeckel, S.; Nees, G.; Sommer, R.; Zhao, Y.; Cherkasov, D.; Hori, H.; Ehm, G.; Schnare, M.; Nain, M.; Kaufmann, A.; Bauer, S.
    The 2-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition (2012), J. Exp. Med., 209, 235-241.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.1.1.34 medicine bacterial tRNA induces type I interferon and inflammatory cytokines in mouse dendritic cells and human peripheral blood mononuclear cells. tRNA from an Escherichia coli knockout strain for tRNA (Gm18)-2'-O-methyltransferase regained immunostimulatory potential. In vitro methylation of this immunostimulatory Gm18-negative tRNA with recombinant trmH from Thermus thermophilus abolishes its interferon-alpha-inducing potential. Gm18-modified tRNA acts as toll-like receptor TLR7 antagonist and blocks IFN-alpha induction of influenza A virus-infected peripheral blood mononuclear cells Escherichia coli
2.1.1.34 medicine in vitro methylation of immunostimulatory Gm18-negative tRNA with recombinant trmH from Thermus thermophilus abolishes its interferon-alpha-inducing potential Thermus thermophilus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.34 Escherichia coli
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2.1.1.34 Thermus thermophilus
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