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Literature summary extracted from

  • Takatsu, H.; Tanaka, G.; Segawa, K.; Suzuki, J.; Nagata, S.; Nakayama, K.; Shin, H.W.
    Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane (2014), J. Biol. Chem., 289, 33543-33556.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
7.6.2.1 analysis assay for phospholipid flippase activities of plasma membrane-localized P4-ATPases using human cell lines stably expressing isoforms ATP8B1, ATP8B2, ATP11A, and ATP11C Homo sapiens
7.6.2.1 medicine some ATP8B1 mutants found in patients of progressive familial intrahepatic cholestasis type 1 (PFIC1), a severe liver disease caused by impaired bile flow, fail to translocate phosphatidylcholine despite their delivery to the plasma membrane. Incorporation of phosphatidylcholine mediated by ATP8B1 can be reversed by simultaneous expression of ABCB4, a phosphatidylcholine floppase mutated in PFIC3 patients Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.1 Homo sapiens O43520
-
-
7.6.2.1 Homo sapiens P98196
-
-
7.6.2.1 Homo sapiens P98198
-
-
7.6.2.1 Homo sapiens Q8NB49
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.1 ATP + H2O + phosphatidylcholine/in
-
 Homo sapiens ADP + phosphate + phosphatidylcholine/out
-
 ?
7.6.2.1 ATP + H2O + phosphatidylcholine/in preferred substrate Homo sapiens ADP + phosphate + phosphatidylcholine/out
-
 ?
7.6.2.1 ATP + H2O + phosphatidylethanolamine/in
-
 Homo sapiens ADP + phosphate + phosphatidylethanolamine/out
-
 ?
7.6.2.1 ATP + H2O + phosphatidylserine/in
-
 Homo sapiens ADP + phosphate + phosphatidylserine/out
-
 ?
7.6.2.1 additional information no substrates: phosphatidylcholine, sphingomyelin Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.1 ATP11A
-
 Homo sapiens
7.6.2.1 ATP11C
-
 Homo sapiens
7.6.2.1 ATP8B1
-
 Homo sapiens
7.6.2.1 ATP8B2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
7.6.2.1 physiological function ATPase-deficient mutants of isoform ATP11A do not exhibit any flippase activity Homo sapiens
7.6.2.1 physiological function ATPase-deficient mutants of isoform ATP11C do not exhibit any flippase activity Homo sapiens