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Literature summary extracted from

  • Mori, Y.; Sugawara, A.; Tsuji, M.; Kakamu, T.; Tsuboi, S.; Kanda, H.; Hayakawa, T.; Fukushima, T.
    Toxic effects of nicotinamide methylation on mouse brain striatum neuronal cells and its relation to manganese (2012), Environ. Health Prev. Med., 17, 371-376.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.1 Cd2+
-
Mus musculus
2.1.1.1 Cu2+
-
Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.1 cytosol
-
Mus musculus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.1 additional information no effect on enzyme activity by Fe2+ and Mn2+, but Mn2+ reduces mouse CD1 brain striatum neuronal cell survival with less than 10% cells surviving at 0.1 mM Mn2+ Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.1 S-adenosyl-L-methionine + nicotinamide Mus musculus
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.1 brain
-
Mus musculus
-
2.1.1.1 neuronal cell CD1 brain striatum neuronal cells Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.1 S-adenosyl-L-methionine + nicotinamide
-
Mus musculus S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.1 NNMT
-
Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.1 37
-
assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.1 8.6
-
assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.1 S-adenosyl-L-methionine
-
Mus musculus

General Information

EC Number General Information Comment Organism
2.1.1.1 malfunction alterations in in vivo enzyme NNMT activity are believed to be negatively associated with gene polymorphism and environmental influences are also considered to be significant Mus musculus
2.1.1.1 additional information nicotinamide and 1-methylnicotinamide are neurotoxic, chronic exposure to Mn2+ plays a role in idiopathic Parkinson's disease associated to 1-methylnicotinamide. But no metal-increased NNMT activity can be measured Mus musculus