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Literature summary extracted from

  • Weinert, C.; Wiese, S.; Rawel, H.; Esatbeyoglu, T.; Winterhalter, P.; Homann, T.; Kulling, S.
    Methylation of catechins and procyanidins by rat and human catechol-o-methyltransferase: Metabolite profiling and molecular modeling studies (2012), Drug Metab. Dispos., 40, 353-359.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.6 cytosol
-
Homo sapiens 5829
-
2.1.1.6 cytosol
-
Rattus norvegicus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Homo sapiens
-
-
-
2.1.1.6 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.6 liver
-
Rattus norvegicus
-
2.1.1.6 placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.6 (+)-catechin + S-adenosyl-L-methionine
-
Homo sapiens S-adenosyl-L-homocysteine + ? 3'-O-methyl derivatives are consistently the main metabolites, 3'-O-methyl derivatives are consistently the main metabolites, meta/para ratio of the metabolites is approximately 25:1 ?
2.1.1.6 (+)-catechin + S-adenosyl-L-methionine
-
Rattus norvegicus S-adenosyl-L-homocysteine + ? 3'-O-methyl derivatives are consistently the main metabolites, 3'-O-methyl derivatives are consistently the main metabolites, meta/para ratio of the metabolites is approximately 25:1 ?
2.1.1.6 (-)-epicatechin + S-adenosyl-L-methionine
-
Homo sapiens S-adenosyl-L-homocysteine + ? 3'-O-methyl derivatives are consistently the main metabolites, the meta/para ratio of the metabolites is approximately 6:1 ?
2.1.1.6 (-)-epicatechin + S-adenosyl-L-methionine
-
Rattus norvegicus S-adenosyl-L-homocysteine + ? 3'-O-methyl derivatives are consistently the main metabolites, the meta/para ratio of the metabolites is approximately 6:1 ?
2.1.1.6 3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine
-
Homo sapiens 4-hydroxy-3-methoxybenzoic acid + S-adenosyl-L-homocysteine the meta/para ratio of the metabolites is approximately 4.5 ?
2.1.1.6 3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine
-
Rattus norvegicus 4-hydroxy-3-methoxybenzoic acid + S-adenosyl-L-homocysteine the meta/para ratio of the metabolites is approximately 4.5 ?
2.1.1.6 additional information degree and position of methylation depend clearly on the three-dimensional structure of the entire substrate molecule Homo sapiens ?
-
?
2.1.1.6 additional information degree and position of methylation depend clearly on the three-dimensional structure of the entire substrate molecule Rattus norvegicus ?
-
?
2.1.1.6 procyanidin dimer B1 + S-adenosyl-L-methionine
-
Homo sapiens S-adenosyl-L-homocysteine + ? flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites ?
2.1.1.6 procyanidin dimer B1 + S-adenosyl-L-methionine
-
Rattus norvegicus S-adenosyl-L-homocysteine + ? flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites ?
2.1.1.6 procyanidin dimer B2 + S-adenosyl-L-methionine
-
Homo sapiens S-adenosyl-L-homocysteine + ? flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites ?
2.1.1.6 procyanidin dimer B2 + S-adenosyl-L-methionine
-
Rattus norvegicus S-adenosyl-L-homocysteine + ? flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites ?
2.1.1.6 procyanidin dimer B3 + S-adenosyl-L-methionine
-
Homo sapiens S-adenosyl-L-homocysteine + ? flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites ?
2.1.1.6 procyanidin dimer B3 + S-adenosyl-L-methionine
-
Rattus norvegicus S-adenosyl-L-homocysteine + ? flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites ?
2.1.1.6 procyanidin dimer B4 + S-adenosyl-L-methionine
-
Homo sapiens S-adenosyl-L-homocysteine + ? flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites ?
2.1.1.6 procyanidin dimer B4 + S-adenosyl-L-methionine
-
Rattus norvegicus S-adenosyl-L-homocysteine + ? flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites ?
2.1.1.6 procyanidin dimer B5 + S-adenosyl-L-methionine
-
Homo sapiens S-adenosyl-L-homocysteine + ? flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites ?
2.1.1.6 procyanidin dimer B5 + S-adenosyl-L-methionine
-
Rattus norvegicus S-adenosyl-L-homocysteine + ? flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites ?
2.1.1.6 procyanidin dimer B7 + S-adenosyl-L-methionine
-
Homo sapiens S-adenosyl-L-homocysteine + ? flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites ?
2.1.1.6 procyanidin dimer B7 + S-adenosyl-L-methionine
-
Rattus norvegicus S-adenosyl-L-homocysteine + ? flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites ?
2.1.1.6 procyanidin trimer C1 + S-adenosyl-L-methionine
-
Homo sapiens S-adenosyl-L-homocysteine + ? flavanyl units of procyanidins are methylated consecutively, leading to monomethylated, dimethylated, and trimethylated C1 metabolites ?
2.1.1.6 procyanidin trimer C1 + S-adenosyl-L-methionine
-
Rattus norvegicus S-adenosyl-L-homocysteine + ? flavanyl units of procyanidins are methylated consecutively, leading to monomethylated, dimethylated, and trimethylated C1 metabolites ?