BRENDA - Enzyme Database

Methylation of catechins and procyanidins by rat and human catechol-o-methyltransferase: Metabolite profiling and molecular modeling studies

Weinert, C.; Wiese, S.; Rawel, H.; Esatbeyoglu, T.; Winterhalter, P.; Homann, T.; Kulling, S.; Drug Metab. Dispos. 40, 353-359 (2012)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.1.1.6
cytosol
-
Rattus norvegicus
5829
-
2.1.1.6
cytosol
-
Homo sapiens
5829
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.6
Homo sapiens
-
-
-
2.1.1.6
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.6
liver
-
Rattus norvegicus
-
2.1.1.6
placenta
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.6
(+)-catechin + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, 3'-O-methyl derivatives are consistently the main metabolites, meta/para ratio of the metabolites is approximately 25:1
-
-
?
2.1.1.6
(+)-catechin + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, 3'-O-methyl derivatives are consistently the main metabolites, meta/para ratio of the metabolites is approximately 25:1
-
-
?
2.1.1.6
(-)-epicatechin + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, the meta/para ratio of the metabolites is approximately 6:1
-
-
?
2.1.1.6
(-)-epicatechin + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, the meta/para ratio of the metabolites is approximately 6:1
-
-
?
2.1.1.6
3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine
-
733709
Homo sapiens
4-hydroxy-3-methoxybenzoic acid + S-adenosyl-L-homocysteine
the meta/para ratio of the metabolites is approximately 4.5
-
-
?
2.1.1.6
3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
4-hydroxy-3-methoxybenzoic acid + S-adenosyl-L-homocysteine
the meta/para ratio of the metabolites is approximately 4.5
-
-
?
2.1.1.6
additional information
degree and position of methylation depend clearly on the three-dimensional structure of the entire substrate molecule
733709
Homo sapiens
?
-
-
-
-
2.1.1.6
additional information
degree and position of methylation depend clearly on the three-dimensional structure of the entire substrate molecule
733709
Rattus norvegicus
?
-
-
-
-
2.1.1.6
procyanidin dimer B1 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B1 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B2 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B2 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B3 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B3 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B4 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B4 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B5 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B5 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B7 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B7 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin trimer C1 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated, dimethylated, and trimethylated C1 metabolites
-
-
?
2.1.1.6
procyanidin trimer C1 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated, dimethylated, and trimethylated C1 metabolites
-
-
?
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.1.1.6
cytosol
-
Rattus norvegicus
5829
-
2.1.1.6
cytosol
-
Homo sapiens
5829
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.6
liver
-
Rattus norvegicus
-
2.1.1.6
placenta
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.6
(+)-catechin + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, 3'-O-methyl derivatives are consistently the main metabolites, meta/para ratio of the metabolites is approximately 25:1
-
-
?
2.1.1.6
(+)-catechin + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, 3'-O-methyl derivatives are consistently the main metabolites, meta/para ratio of the metabolites is approximately 25:1
-
-
?
2.1.1.6
(-)-epicatechin + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, the meta/para ratio of the metabolites is approximately 6:1
-
-
?
2.1.1.6
(-)-epicatechin + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, the meta/para ratio of the metabolites is approximately 6:1
-
-
?
2.1.1.6
3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine
-
733709
Homo sapiens
4-hydroxy-3-methoxybenzoic acid + S-adenosyl-L-homocysteine
the meta/para ratio of the metabolites is approximately 4.5
-
-
?
2.1.1.6
3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
4-hydroxy-3-methoxybenzoic acid + S-adenosyl-L-homocysteine
the meta/para ratio of the metabolites is approximately 4.5
-
-
?
2.1.1.6
additional information
degree and position of methylation depend clearly on the three-dimensional structure of the entire substrate molecule
733709
Homo sapiens
?
-
-
-
-
2.1.1.6
additional information
degree and position of methylation depend clearly on the three-dimensional structure of the entire substrate molecule
733709
Rattus norvegicus
?
-
-
-
-
2.1.1.6
procyanidin dimer B1 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B1 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B2 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B2 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B3 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B3 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B4 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B4 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B5 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B5 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B7 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin dimer B7 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
2.1.1.6
procyanidin trimer C1 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated, dimethylated, and trimethylated C1 metabolites
-
-
?
2.1.1.6
procyanidin trimer C1 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated, dimethylated, and trimethylated C1 metabolites
-
-
?