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Literature summary extracted from

  • Lee, S.G.; Alpert, T.D.; Jez, J.M.
    Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine (2012), Bioorg. Med. Chem. Lett., 22, 4990-4993.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.1.103 in complex with amodiaquine, hanging drop vapor diffusion method Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.103 amodiaquine i.e. 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol Plasmodium falciparum
2.1.1.103 Chloroquine
-
 Plasmodium falciparum
2.1.1.103 primaquine
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.103 S-adenosyl-L-methionine + ethanolamine phosphate Plasmodium falciparum
-
 S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.103 Plasmodium falciparum Q6T755
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.103 S-adenosyl-L-methionine + ethanolamine phosphate
-
 Plasmodium falciparum S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.103 phosphoethanolamine methyltransferase
-
 Plasmodium falciparum
2.1.1.103 PMT
-
 Plasmodium falciparum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.1.103 0.46
-
 pH and temperature not specified in the publication Plasmodium falciparum primaquine
2.1.1.103 0.554
-
 pH and temperature not specified in the publication Plasmodium falciparum Chloroquine
2.1.1.103 1.35
-
 pH and temperature not specified in the publication Plasmodium falciparum amodiaquine