Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sun, X.; Zhang, X.; Jiang, Y.; Bao, S.; Shan, Z.; Teng, W.
    Expression of iodotyrosine deiodinase in thyroid and other organs in iodine-deficient and iodine-excess rats (2015), Biol. Trace Elem. Res., 167, 272-279.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.21.1.1 quantitative RT-PCR enzyme expression analysis, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.1.1 L-tyrosine + 2 NADP+ + 2 iodide Rattus norvegicus
-
 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+
-
 r
1.21.1.1 L-tyrosine + 2 NADP+ + 2 iodide Rattus norvegicus Wistar
-
 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.21.1.1 Rattus norvegicus
-
 female
-
1.21.1.1 Rattus norvegicus Wistar
-
 female
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.1.1 kidney
-
 Rattus norvegicus
-
1.21.1.1 liver
-
 Rattus norvegicus
-
1.21.1.1 additional information tissue expression analysis of the enzyme in conditions such as iodine deficiency and excess, overview Rattus norvegicus
-
1.21.1.1 thyroid
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.1.1 L-tyrosine + 2 NADP+ + 2 iodide
-
 Rattus norvegicus 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+
-
 r
1.21.1.1 L-tyrosine + 2 NADP+ + 2 iodide
-
 Rattus norvegicus Wistar 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.21.1.1 IYD
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.21.1.1 flavin a flavin mononucleotide-dependent deiodinase Rattus norvegicus
1.21.1.1 NADPH dependent on Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.21.1.1 Rattus norvegicus the enzyme is suppressed in liver and kidney by iodine intake. Excess iodine decreases the expression of thyroidal enzyme down
1.21.1.1 Rattus norvegicus iodine deficiency results in an increased enzyme expression in thyroid up

General Information

EC Number General Information Comment Organism
1.21.1.1 physiological function the enzyme, catalyzing the reductive dehalogenation, is a critical enzyme in maintaining iodine homeostasis Rattus norvegicus