BRENDA - Enzyme Database show

Role of arsenic (+3 oxidation state) methyltransferase in arsenic metabolism and toxicity

Sumi, D.; Himeno, S.; Biol. Pharm. Bull. 35, 1870-1875 (2012)

Data extracted from this reference:

Engineering
EC Number
Amino acid exchange
Commentary
Organism
2.1.1.137
M287T
the substitution results in an increase in the capacity of the first step of methylation, leading to an increase in the percentage of urinary methylarsonate, but not the second step of methylation
Homo sapiens
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.1.1.137
41700
-
x * 41700, calculated from amino acid sequence
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
Homo sapiens
-
S-adenosyl-L-homocysteine + methylarsonate
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
Homo sapiens
-
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.137
Homo sapiens
Q9HBK9
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.137
A-549 cell
-
Homo sapiens
-
2.1.1.137
HEK-293 cell
-
Homo sapiens
-
2.1.1.137
Hep-G2 cell
-
Homo sapiens
-
2.1.1.137
HL-60 cell
-
Homo sapiens
-
2.1.1.137
K-562 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
733451
Homo sapiens
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
-
733451
Homo sapiens
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
2.1.1.137
?
x * 41700, calculated from amino acid sequence
Homo sapiens
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
2.1.1.137
M287T
the substitution results in an increase in the capacity of the first step of methylation, leading to an increase in the percentage of urinary methylarsonate, but not the second step of methylation
Homo sapiens
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.1.1.137
41700
-
x * 41700, calculated from amino acid sequence
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
Homo sapiens
-
S-adenosyl-L-homocysteine + methylarsonate
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
Homo sapiens
-
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.137
A-549 cell
-
Homo sapiens
-
2.1.1.137
HEK-293 cell
-
Homo sapiens
-
2.1.1.137
Hep-G2 cell
-
Homo sapiens
-
2.1.1.137
HL-60 cell
-
Homo sapiens
-
2.1.1.137
K-562 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
733451
Homo sapiens
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
-
733451
Homo sapiens
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.1.1.137
?
x * 41700, calculated from amino acid sequence
Homo sapiens