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Literature summary extracted from

  • Xie, X.; Yu, H.; Wang, Y.; Zhou, Y.; Li, G.; Ruan, Z.; Li, F.; Wang, X.; Liu, H.; Zhang, J.
    Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells (2014), Arch. Biochem. Biophys., 564, 52-66.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.1 recombinant overexpression of enzyme NNMT in colorectal cancer cells line SW480 which lacks constitutive NNMT expression, quantitative real-time PCR analysis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.1 additional information downregulation of enzyme NNMT expression in HT-29 cells. Balb/c mice are injected with NNMT-transfected SW-480 cells, the enzyme significantly accelerates cell proliferation and enhances tumorigenicity in mice Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.1 cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.1 S-adenosyl-L-methionine + nicotinamide Homo sapiens
-
 S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.1 colorectal cancer cell
-
 Homo sapiens
-
2.1.1.1 HT-29 cell exhibit high endogenous expression of enzyme NNMT Homo sapiens
-
2.1.1.1 additional information nicotinamide N-methyltransferase is overexpressed in several malignancies, including colorectal cancer cells. No constitutive expresion of the enzyme in colorectal cancer cells line SW480 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.1 S-adenosyl-L-methionine + nicotinamide
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.1 NNMT
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.1 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.1 8.6
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.1 S-adenosyl-L-methionine
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.1.1.1 physiological function nicotinamide N-methyltransferase is involved in the biotransformation and detoxification of many drugs and xenobiotic compounds, it enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells. The enzyme significantly accelerates cell proliferation, enhances colony formation in vitro and tumorigenicity in mice, and inhibits apoptosis, it promotes cell cycle progression, increases ATP and 1-methylnicotinamide level and decreases ROS levels. 1-Methylnicotinamide also accelerates cell growth, inhibits apoptosis, promotes cell cycle progression, attenuates ROS production and increases ATP levels. The enzyme may play a vital role in energy balance and ROS induction, 1-Methylnicotinamide is beneficial in conditions such as inflammation and antioxidation Homo sapiens