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Literature summary extracted from

  • McKay, G.A.; Roestamadji, J.; Mobashery, S.; Wright, G.D.
    Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: role of substrate amino groups (1996), Antimicrob. Agents Chemother., 40, 2648-2650.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.B26 kanamycin
-
Enterococcus faecium
2.7.1.B26 neamine
-
Enterococcus faecium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.B26 0.0071
-
3-deaminoneamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 0.0126
-
kanamycin A pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 0.02
-
neamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 0.0359
-
2'-deaminoneamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 0.0518
-
1-deaminoneamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 0.0818
-
6'-deaminoneamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.B26 Enterococcus faecium E9LMR8
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.B26 additional information protein contains no disulfide bonds Enterococcus faecium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.B26 GTP + 1-deaminoneamine
-
Enterococcus faecium GDP + 1-deaminoneamine 3'-phosphate
-
?
2.7.1.B26 GTP + 2'-deaminoneamine
-
Enterococcus faecium GDP + 2'-deaminoneamine 3'-phosphate
-
?
2.7.1.B26 GTP + 3-deaminoneamine
-
Enterococcus faecium GDP + 3-deaminoneamine 3'-phosphate
-
?
2.7.1.B26 GTP + 6'-deaminoneamine
-
Enterococcus faecium GDP + 6'-deaminoneamine 3'-phosphate
-
?
2.7.1.B26 GTP + kanamycin A
-
Enterococcus faecium GDP + kanamycin A 3'-phosphate
-
?
2.7.1.B26 GTP + neamine
-
Enterococcus faecium GDP + neamine 3'-phosphate
-
?
2.7.1.B26 additional information an amino group on C-1 and either an amino or a hydroxyl group at the 2' and 6' positions are important for detoxification of aminoglycosides by the enzyme Enterococcus faecium ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.B26 APH-3'-IIIa
-
Enterococcus faecium
2.7.1.B26 Aph3
-
Enterococcus faecium

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.1.B26 0.278
-
6'-deaminoneamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 0.39
-
2'-deaminoneamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 1.03
-
1-deaminoneamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 1.16
-
3-deaminoneamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 1.76
-
kanamycin A pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 2
-
neamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.B26 2
-
neamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 6.3
-
kanamycin pH not specified in the publication, temperature not specified in the publication Enterococcus faecium

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.7.1.B26 3.4
-
kanamycin A pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 11
-
6'-deaminoneamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 20
-
3-deaminoneamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 100
-
1-deaminoneamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium
2.7.1.B26 160
-
2'-deaminoneamine pH not specified in the publication, temperature not specified in the publication Enterococcus faecium