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Literature summary extracted from
- Meprin A metalloproteinase and its role in acute kidney injury (2013), Am. J. Physiol. Renal Physiol., 304, F1150-F1158.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.18 | actinonin | - |
Homo sapiens |  |
| 3.4.24.18 | actinonin | - |
Mus musculus | |
| 3.4.24.18 | actinonin | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.18 | brush border membrane | brush-border membranes of proximal tubules and intestines | Mus musculus | 31526 | - |
| 3.4.24.18 | brush border membrane | brush-border membranes of proximal tubules and intestines | Homo sapiens | 31526 | - |
| 3.4.24.18 | brush border membrane | brush-border membranes of proximal tubules and intestines | Rattus norvegicus | 31526 | - |
| 3.4.24.18 | extracellular | shedded meprin A | Mus musculus | - |
- |
| 3.4.24.18 | extracellular | shedded meprin A | Homo sapiens | - |
- |
| 3.4.24.18 | extracellular | shedded meprin A | Rattus norvegicus | - |
- |
| 3.4.24.18 | membrane | meprin A, is a membrane-associated neutral metalloendoprotease. Importance of a sheddase involved in the release of membrane-associated meprin A under pathological conditions | Mus musculus | 16020 | - |
| 3.4.24.18 | membrane | meprin A, is a membrane-associated neutral metalloendoprotease. Importance of a sheddase involved in the release of membrane-associated meprin A under pathological conditions | Homo sapiens | 16020 | - |
| 3.4.24.18 | membrane | meprin A, is a membrane-associated neutral metalloendoprotease. Importance of a sheddase involved in the release of membrane-associated meprin A under pathological conditions | Rattus norvegicus | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.18 | Zn2+ | a neutral metalloendoprotease | Mus musculus | |
| 3.4.24.18 | Zn2+ | a neutral metalloendoprotease | Homo sapiens | |
| 3.4.24.18 | Zn2+ | a neutral metalloendoprotease | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.18 | alpha-melanocyte-stimulating hormone + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.24.18 | angiotensin I + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.24.18 | angiotensin I + H2O | Homo sapiens | in human small intestine | ? | - |
? | |
| 3.4.24.18 | angiotensin II + H2O | Homo sapiens | in human small intestine | ? | - |
? | |
| 3.4.24.18 | angiotensin II + H2O | Mus musculus | in mouse kidney | ? | - |
? | |
| 3.4.24.18 | bombesin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.24.18 | bradykinin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.24.18 | bradykinin + H2O | Homo sapiens | in human small intestine | ? | - |
? | |
| 3.4.24.18 | bradykinin + H2O | Mus musculus | in mouse kidney | ? | - |
? | |
| 3.4.24.18 | bradykinin + H2O | Rattus norvegicus | in rat kidney | ? | - |
? | |
| 3.4.24.18 | catalytic subunit of protein kinase A + H2O | Rattus norvegicus | in rat kidney | ? | - |
? | |
| 3.4.24.18 | CCK8NH2 + H2O | Mus musculus | - |
L-Asp-L-Tyr-L-Met-Gly-L-Trp-L-Met + L-Asp-L-Phe | - |
? | |
| 3.4.24.18 | cerulein + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.24.18 | Collagen IV + H2O | Rattus norvegicus | in rat kidney | ? | - |
? | |
| 3.4.24.18 | Fibronectin + H2O | Rattus norvegicus | in rat kidney | ? | - |
? | |
| 3.4.24.18 | gastrin-releasing peptide-(14-27) + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.24.18 | Gelatin + H2O | Rattus norvegicus | in rat kidney | ? | - |
? | |
| 3.4.24.18 | Glucagon + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.24.18 | insulin + H2O | Mus musculus | in mouse kidney | ? | - |
? | |
| 3.4.24.18 | insulin B chain + H2O | Homo sapiens | in human small intestine | ? | - |
? | |
| 3.4.24.18 | Laminin + H2O | Rattus norvegicus | in rat kidney | ? | - |
? | |
| 3.4.24.18 | luteinizing-hormone-releasing hormone + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.24.18 | luteinizing-hormone-releasing hormone + H2O | Homo sapiens | in human small intestine | ? | - |
? | |
| 3.4.24.18 | luteinizing-hormone-releasing hormone + H2O | Rattus norvegicus | in rat kidney | ? | - |
? | |
| 3.4.24.18 | additional information | Mus musculus | the enzyme is capable of hydrolyzing and processing a large number of substrates, including extracellular matrix proteins, cytokines, adherens junction proteins, hormones, bioactive peptides, and cell surface proteins | ? | - |
? | |
| 3.4.24.18 | additional information | Homo sapiens | the enzyme is capable of hydrolyzing and processing a large number of substrates, including extracellular matrix proteins, cytokines, adherens junction proteins, hormones, bioactive peptides, and cell surface proteins | ? | - |
? | |
| 3.4.24.18 | additional information | Rattus norvegicus | the enzyme is capable of hydrolyzing and processing a large number of substrates, including extracellular matrix proteins, cytokines, adherens junction proteins, hormones, bioactive peptides, and cell surface proteins | ? | - |
? | |
| 3.4.24.18 | additional information | Mus musculus C57BL/6N | the enzyme is capable of hydrolyzing and processing a large number of substrates, including extracellular matrix proteins, cytokines, adherens junction proteins, hormones, bioactive peptides, and cell surface proteins | ? | - |
? | |
| 3.4.24.18 | neuropeptide Y + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.24.18 | neurotensin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.24.18 | neurotensin + H2O | Mus musculus C57BL/6N | - |
? | - |
? | |
| 3.4.24.18 | Nidogen + H2O | Rattus norvegicus | in rat kidney | ? | - |
? | |
| 3.4.24.18 | oxytocin + H2O | Homo sapiens | in human small intestine | ? | - |
? | |
| 3.4.24.18 | Parathyroid hormone + H2O | Rattus norvegicus | in rat kidney | ? | - |
? | |
| 3.4.24.18 | parathyroid hormone fragment 13-34 + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.24.18 | Pro-interleukin-1beta + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.24.18 | Secretin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.24.18 | Substance P + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.24.18 | Substance P + H2O | Homo sapiens | in human small intestine | ? | - |
? | |
| 3.4.24.18 | Substance P + H2O | Rattus norvegicus | in rat kidney | ? | - |
? | |
| 3.4.24.18 | tumor necrosis factor alpha + H2O | Rattus norvegicus | in rat kidney | ? | - |
? | |
| 3.4.24.18 | valosin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.24.18 | Vasoactive intestinal peptide + H2O | Mus musculus | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.18 | Homo sapiens | - |
- |
- |
| 3.4.24.18 | Mus musculus | - |
- |
- |
| 3.4.24.18 | Mus musculus C57BL/6N | - |
- |
- |
| 3.4.24.18 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.18 | bladder | - |
Mus musculus | - |
| 3.4.24.18 | bladder | - |
Homo sapiens | - |
| 3.4.24.18 | bladder | - |
Rattus norvegicus | - |
| 3.4.24.18 | brain | - |
Mus musculus | - |
| 3.4.24.18 | brain | - |
Homo sapiens | - |
| 3.4.24.18 | brain | - |
Rattus norvegicus | - |
| 3.4.24.18 | breast cancer cell | - |
Mus musculus | - |
| 3.4.24.18 | breast cancer cell | - |
Homo sapiens | - |
| 3.4.24.18 | breast cancer cell | - |
Rattus norvegicus | - |
| 3.4.24.18 | colorectal carcinoma cell | - |
Mus musculus | - |
| 3.4.24.18 | colorectal carcinoma cell | - |
Homo sapiens | - |
| 3.4.24.18 | colorectal carcinoma cell | - |
Rattus norvegicus | - |
| 3.4.24.18 | epithelium | - |
Mus musculus | - |
| 3.4.24.18 | epithelium | - |
Homo sapiens | - |
| 3.4.24.18 | epithelium | - |
Rattus norvegicus | - |
| 3.4.24.18 | gastrointestinal cancer cell | - |
Mus musculus | - |
| 3.4.24.18 | gastrointestinal cancer cell | - |
Homo sapiens | - |
| 3.4.24.18 | gastrointestinal cancer cell | - |
Rattus norvegicus | - |
| 3.4.24.18 | kidney | - |
Homo sapiens | - |
| 3.4.24.18 | kidney | - |
Rattus norvegicus | - |
| 3.4.24.18 | kidney | meprin A distribution in the mouse kidney, immunolacalization, overview | Mus musculus | - |
| 3.4.24.18 | large intestine | - |
Mus musculus | - |
| 3.4.24.18 | large intestine | - |
Homo sapiens | - |
| 3.4.24.18 | large intestine | - |
Rattus norvegicus | - |
| 3.4.24.18 | leukocyte | - |
Mus musculus | - |
| 3.4.24.18 | leukocyte | - |
Homo sapiens | - |
| 3.4.24.18 | leukocyte | - |
Rattus norvegicus | - |
| 3.4.24.18 | MDA-MB-435 cell | - |
Homo sapiens | - |
| 3.4.24.18 | mesenteric lymph node | - |
Mus musculus | - |
| 3.4.24.18 | mesenteric lymph node | - |
Homo sapiens | - |
| 3.4.24.18 | mesenteric lymph node | - |
Rattus norvegicus | - |
| 3.4.24.18 | mucinous ovarian adenocarcinoma cell | primary | Mus musculus | - |
| 3.4.24.18 | mucinous ovarian adenocarcinoma cell | primary | Homo sapiens | - |
| 3.4.24.18 | mucinous ovarian adenocarcinoma cell | primary | Rattus norvegicus | - |
| 3.4.24.18 | skin | epithelium | Mus musculus | - |
| 3.4.24.18 | skin | epithelium | Homo sapiens | - |
| 3.4.24.18 | skin | epithelium | Rattus norvegicus | - |
| 3.4.24.18 | small intestine | - |
Mus musculus | - |
| 3.4.24.18 | small intestine | - |
Homo sapiens | - |
| 3.4.24.18 | small intestine | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.18 | actin + H2O | murine homomeric recombinant enzyme | Mus musculus | ? | - |
? | |
| 3.4.24.18 | alpha-melanocyte-stimulating hormone + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | alpha-melanocyte-stimulating hormone + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | alpha-melanocyte-stimulating hormone + H2O | murine homomeric recombinant enzyme | Mus musculus | ? | - |
? | |
| 3.4.24.18 | angiotensin I + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | angiotensin I + H2O | in human small intestine | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | angiotensin II + H2O | in human small intestine | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | angiotensin II + H2O | in mouse kidney | Mus musculus | ? | - |
? | |
| 3.4.24.18 | azocasein + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | azocasein + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.18 | azocasein + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | azocasein + H2O | - |
Mus musculus C57BL/6N | ? | - |
? | |
| 3.4.24.18 | benzoyl-L-tyrosyl-4-aminobenzoic acid + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | benzoyl-L-tyrosyl-4-aminobenzoic acid + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.18 | benzoyl-L-tyrosyl-4-aminobenzoic acid + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | bombesin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | bradykinin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | bradykinin + H2O | in human small intestine | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | bradykinin + H2O | in mouse kidney | Mus musculus | ? | - |
? | |
| 3.4.24.18 | bradykinin + H2O | in rat kidney | Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | bradykinin + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | bradykinin + H2O | murine homomeric recombinant enzyme | Mus musculus | ? | - |
? | |
| 3.4.24.18 | catalytic subunit of protein kinase A + H2O | in rat kidney | Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | CCK8 nonsulfated + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | CCK8 nonsulfated + H2O | murine homomeric recombinant enzyme | Mus musculus | ? | - |
? | |
| 3.4.24.18 | CCK8NH2 + H2O | - |
Mus musculus | L-Asp-L-Tyr-L-Met-Gly-L-Trp-L-Met + L-Asp-L-Phe | - |
? | |
| 3.4.24.18 | cerulein + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | Collagen IV + H2O | in rat kidney | Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | collagen type IV + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | Fibronectin + H2O | in rat kidney | Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | Fibronectin + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | gastrin-releasing peptide + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | gastrin-releasing peptide + H2O | murine homomeric recombinant enzyme | Mus musculus | ? | - |
? | |
| 3.4.24.18 | gastrin-releasing peptide-(14-27) + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | Gelatin + H2O | in rat kidney | Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | ghrelin + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | ghrelin + H2O | murine homomeric recombinant enzyme | Mus musculus | ? | - |
? | |
| 3.4.24.18 | Glucagon + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | Glucagon + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | Glucagon + H2O | murine homomeric recombinant enzyme | Mus musculus | ? | - |
? | |
| 3.4.24.18 | insulin + H2O | in mouse kidney | Mus musculus | ? | - |
? | |
| 3.4.24.18 | insulin B chain + H2O | in human small intestine | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | Laminin + H2O | in rat kidney | Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | laminin 1 + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | laminin 5 + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | luteinizing-hormone-releasing hormone + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | luteinizing-hormone-releasing hormone + H2O | in human small intestine | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | luteinizing-hormone-releasing hormone + H2O | in rat kidney | Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | luteinizing-hormone-releasing hormone + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | luteinizing-hormone-releasing hormone + H2O | murine homomeric recombinant enzyme | Mus musculus | ? | - |
? | |
| 3.4.24.18 | additional information | the enzyme is capable of hydrolyzing and processing a large number of substrates, including extracellular matrix proteins, cytokines, adherens junction proteins, hormones, bioactive peptides, and cell surface proteins | Mus musculus | ? | - |
? | |
| 3.4.24.18 | additional information | the enzyme is capable of hydrolyzing and processing a large number of substrates, including extracellular matrix proteins, cytokines, adherens junction proteins, hormones, bioactive peptides, and cell surface proteins | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | additional information | the enzyme is capable of hydrolyzing and processing a large number of substrates, including extracellular matrix proteins, cytokines, adherens junction proteins, hormones, bioactive peptides, and cell surface proteins | Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | additional information | the enzyme is capable of hydrolyzing and processing a large number of substrates, including extracellular matrix proteins, cytokines, adherens junction proteins, hormones, bioactive peptides, and cell surface proteins | Mus musculus C57BL/6N | ? | - |
? | |
| 3.4.24.18 | neuropeptide Y + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | neurotensin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | neurotensin + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | neurotensin + H2O | murine homomeric recombinant enzyme | Mus musculus | ? | - |
? | |
| 3.4.24.18 | neurotensin + H2O | - |
Mus musculus C57BL/6N | ? | - |
? | |
| 3.4.24.18 | neurotensin + H2O | murine homomeric recombinant enzyme | Mus musculus C57BL/6N | ? | - |
? | |
| 3.4.24.18 | Nidogen + H2O | in rat kidney | Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | nidogen-1 + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | oxytocin + H2O | in human small intestine | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | Parathyroid hormone + H2O | in rat kidney | Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | Parathyroid hormone + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | Parathyroid hormone + H2O | murine homomeric recombinant enzyme | Mus musculus | ? | - |
? | |
| 3.4.24.18 | Parathyroid hormone + H2O | murine homomeric recombinant enzyme | Mus musculus C57BL/6N | ? | - |
? | |
| 3.4.24.18 | parathyroid hormone fragment 13-34 + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | Pro-interleukin-1beta + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | procollagen type III + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | Secretin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | Secretin + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | Secretin + H2O | murine homomeric recombinant enzyme | Mus musculus | ? | - |
? | |
| 3.4.24.18 | Substance P + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | Substance P + H2O | in human small intestine | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | Substance P + H2O | in rat kidney | Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | Substance P + H2O | human homomeric recombinant enzyme | Homo sapiens | ? | - |
? | |
| 3.4.24.18 | Substance P + H2O | murine homomeric recombinant enzyme | Mus musculus | ? | - |
? | |
| 3.4.24.18 | tumor necrosis factor alpha + H2O | in rat kidney | Rattus norvegicus | ? | - |
? | |
| 3.4.24.18 | valosin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | Vasoactive intestinal peptide + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.18 | villin + H2O | murine homomeric recombinant enzyme | Mus musculus | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.24.18 | heterodimer | meprin A is composed of alpha- and beta-subunits | Mus musculus |
| 3.4.24.18 | heterodimer | meprin A is composed of alpha- and beta-subunits | Homo sapiens |
| 3.4.24.18 | heterodimer | meprin A is composed of alpha- and beta-subunits | Rattus norvegicus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.18 | meprin A metalloproteinase | - |
Mus musculus |
| 3.4.24.18 | meprin A metalloproteinase | - |
Homo sapiens |
| 3.4.24.18 | meprin A metalloproteinase | - |
Rattus norvegicus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.24.18 | evolution | meprin A, is a membrane-associated neutral metalloendoprotease that belongs to the astacin family of zinc endopeptidases | Mus musculus |
| 3.4.24.18 | evolution | meprin A, is a membrane-associated neutral metalloendoprotease that belongs to the astacin family of zinc endopeptidases | Homo sapiens |
| 3.4.24.18 | evolution | meprin A, is a membrane-associated neutral metalloendoprotease that belongs to the astacin family of zinc endopeptidases | Rattus norvegicus |
| 3.4.24.18 | malfunction | altered localization and shedding of meprin A in places other than the apical membranes may be deleterious in vivo in acute tubular injury. Importance of a sheddase involved in the release of membrane-associated meprin A under pathological conditions | Mus musculus |
| 3.4.24.18 | malfunction | altered localization and shedding of meprin A in places other than the apical membranes may be deleterious in vivo in acute tubular injury. Importance of a sheddase involved in the release of membrane-associated meprin A under pathological conditions | Rattus norvegicus |
| 3.4.24.18 | malfunction | breast cancer MDA-MB-435 cells treated with the meprin inhibitor actinonin are less invasive in vitro. Altered localization and shedding of meprin A in places other than the apical membranes may be deleterious in vivo in acute tubular injury. Importance of a sheddase involved in the release of membrane-associated meprin A under pathological conditions | Homo sapiens |
| 3.4.24.18 | metabolism | following ischemia-reperfusion- and cisplatin-induced acute kidney injury, meprin A is redistributed toward the basolateral plasma membrane, and the cleaved form of meprin A is excreted in the urine | Mus musculus |
| 3.4.24.18 | metabolism | following ischemia-reperfusion- and cisplatin-induced acute kidney injury, meprin A is redistributed toward the basolateral plasma membrane, and the cleaved form of meprin A is excreted in the urine | Homo sapiens |
| 3.4.24.18 | metabolism | following ischemia-reperfusion- and cisplatin-induced acute kidney injury, meprin A is redistributed toward the basolateral plasma membrane, and the cleaved form of meprin A is excreted in the urine | Rattus norvegicus |
| 3.4.24.18 | physiological function | the enzyme is involved in the progression of colon cancer, the ability of meprins to degrade extracellular matrix components is implicated in cell migration of leukocytes of mesenteric lymph nodes and invasion of tumor cells that express meprin | Homo sapiens |
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Release 2023.1 (January 2023)
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