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Literature summary extracted from

  • Pluskal, T.; Ueno, M.; Yanagida, M.
    Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system (2014), PLoS One, 9, e97774.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.21.3.10 Fe2+ the enzyme requires Fe2+ for activity Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.50 hercynine + gamma-L-glutamyl-L-cysteine + O2 Mycolicibacterium smegmatis the enzyme is part of the biosynthesis pathway of ergothioneine gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
-
 ?
1.21.3.10 hercynine + L-cysteine + O2 Schizosaccharomyces pombe the enzyme is part of the biosynthesis pathway of ergothioneine S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.50 Mycolicibacterium smegmatis
-
-
-
1.21.3.10 Schizosaccharomyces pombe
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.50 hercynine + gamma-L-glutamyl-L-cysteine + O2 the enzyme is part of the biosynthesis pathway of ergothioneine Mycolicibacterium smegmatis gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
-
 ?
1.21.3.10 hercynine + L-cysteine + O2 the enzyme is part of the biosynthesis pathway of ergothioneine Schizosaccharomyces pombe S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
-
 ?
1.21.3.10 hercynine + L-cysteine + O2 hercynine i.e. Nalpha,Nalpha,Nalpha-trimethyl-L-histidine Schizosaccharomyces pombe S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
-
 ?
1.21.3.10 hercynine + L-selenocysteine + O2 hercynine i.e. Nalpha,Nalpha,Nalpha-trimethyl-L-histidine Schizosaccharomyces pombe S-(hercyn-2-yl)-L-selenocysteine S-oxide + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.21.3.10 More the enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44, L-histidine Nalpha-methyltransferase Schizosaccharomyces pombe

Synonyms

EC Number Synonyms Comment Organism
1.21.3.10 Egt-1
-
 Schizosaccharomyces pombe
1.21.3.10 Egt1
-
 Schizosaccharomyces pombe

General Information

EC Number General Information Comment Organism
1.14.99.50 metabolism the enzyme is part of the biosynthesis pathway of ergothioneine Mycolicibacterium smegmatis
1.21.3.10 malfunction the DELTA egt1 deletion mutant shows a complete absence of ergothioneine and all its precursors Schizosaccharomyces pombe