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Literature summary extracted from

  • Vilchez Larrea, S.C.; Schlesinger, M.; Kevorkian, M.L.; Flawia, M.M.; Alonso, G.D.; Fernandez Villamil, S.H.
    Host cell poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycle (2013), PLoS ONE, 8, e67356.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.2.1.143 medicine the enzyme is a promising therapeutic target for the treatment of Chagas' disease Trypanosoma cruzi
3.2.1.143 pharmacology the enzyme is a promising therapeutic target for the treatment of Chagas' disease Trypanosoma cruzi

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.143 6,9-diamino-2-ethoxyacridine lactate
-
 Trypanosoma cruzi
3.2.1.143 adenosine diphosphate (hydroxymethyl) pyrrolidinediol
-
 Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.143 nucleus the enzyme is localized in the nucleus independently of the presence of DNA damage or cell cycle stage Trypanosoma cruzi 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.143 poly(ADP-D-ribose)n + H2O Trypanosoma cruzi
-
 poly(ADP-D-ribose)n-1 + ADP-ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.143 Trypanosoma cruzi Q0PW90
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.143 epimastigote the enzyme is expressed in a life stage-dependant manner Trypanosoma cruzi
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.143 poly(ADP-D-ribose)n + H2O
-
 Trypanosoma cruzi poly(ADP-D-ribose)n-1 + ADP-ribose
-
 ?

General Information

EC Number General Information Comment Organism
3.2.1.143 evolution conservation of key residues involved in the catalytic process Trypanosoma cruzi
3.2.1.143 malfunction lack of poly(ADPribose) glycohydrolase activity in Vero and A549 host cells, achieved by chemical inhibition or iRNA, produces the reduction of the percentage of infected cells as well as the number of amastigotes per cell and trypomastigotes released, leading to a nearly complete abrogation of the infection process Trypanosoma cruzi
3.2.1.143 physiological function poly(ADP-ribose) glycohydrolase (PARG) represents the main poly(ADP-D-ribose) hydrolyzing activity in the cell to ADP-ribose units. The enzyme is crucial for Trypanosoma cruzi infection cycle in the human host cell. Both, Trypanosoma cruzi and the human host, poly(ADP-ribose) glycohydrolase activities are important players in the life cycle of Trypanosoma cruzi Trypanosoma cruzi