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Literature summary extracted from

  • Personne, Y.; Brown, A.; Schuessler, D.; Parish, T.
    Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities (2013), PLoS ONE, 8, e60228.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.92 Mycobacterium tuberculosis P9WPC3 protease subunit ClpP2
-
3.4.21.92 Mycobacterium tuberculosis P9WPC5 protease subunit ClpP1
-
3.4.21.92 Mycobacterium tuberculosis H37Rv P9WPC3 protease subunit ClpP2
-
3.4.21.92 Mycobacterium tuberculosis H37Rv P9WPC5 protease subunit ClpP1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.92 LacZ + H2O
-
 Mycobacterium tuberculosis ? proteolytic subunit ClpP2 over-expression induces degradation of untagged LacZ ?
3.4.21.92 LacZ + H2O
-
 Mycobacterium tuberculosis H37Rv ? proteolytic subunit ClpP2 over-expression induces degradation of untagged LacZ ?
3.4.21.92 additional information the SsrA tag directs proteins to degradation by both ClpP1 and ClpP2. The terminal three residues of the ssrA-tag sequence are LAA. A LAA-tag is sufficient to direct proteins into the degradation pathway Mycobacterium tuberculosis ?
-
 ?
3.4.21.92 additional information the SsrA tag directs proteins to degradation by both ClpP1 and ClpP2. The terminal three residues of the ssrA-tag sequence are LAA. A LAA-tag is sufficient to direct proteins into the degradation pathway Mycobacterium tuberculosis H37Rv ?
-
 ?
3.4.21.92 SsrA-tagged LacZ + H2O both proteolytic subunits ClpP1 and ClpP2 degrade SsrA-tagged LacZ Mycobacterium tuberculosis ?
-
 ?
3.4.21.92 SsrA-tagged LacZ + H2O both proteolytic subunits ClpP1 and ClpP2 degrade SsrA-tagged LacZ Mycobacterium tuberculosis H37Rv ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.92 ATP-dependent Clp protease proteolytic subunit 1
-
 Mycobacterium tuberculosis
3.4.21.92 ATP-dependent Clp protease proteolytic subunit 2
-
 Mycobacterium tuberculosis
3.4.21.92 ClpP1
-
 Mycobacterium tuberculosis
3.4.21.92 ClpP2
-
 Mycobacterium tuberculosis

Expression

EC Number Organism Comment Expression
3.4.21.92 Mycobacterium tuberculosis proteolytic subunits ClpP1 and ClpP2 are co-expressed under normal growth conditions with a single promoter region for the clpP1P2 operon additional information