EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.382 | expression in Escherichia coli | Thermacetogenium phaeum |
1.1.1.382 | expression in Escherichia coli | uncultured archaeon |
1.1.1.382 | expression in Escherichia coli | Desulfosudis oleivorans |
1.1.1.382 | expression in Escherichia coli | Archaeoglobus fulgidus |
1.1.1.383 | expression in Escherichia coli | Metallosphaera sedula |
1.1.1.383 | expression in Escherichia coli | Hydrogenobaculum sp. Y04AAS1 |
1.1.1.383 | expression in Escherichia coli | Ignisphaera aggregans |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.382 | additional information | - |
NADH | Km-value for NADH is below 0.001 mM, pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Thermacetogenium phaeum | |
1.1.1.382 | 0.005 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Archaeoglobus fulgidus | |
1.1.1.382 | 0.032 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Desulfosudis oleivorans | |
1.1.1.382 | 1.1 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | uncultured archaeon | |
1.1.1.383 | additional information | - |
NADH | Km-value for NADH is below 0.001 mM, pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Ignisphaera aggregans | |
1.1.1.383 | additional information | - |
NADPH | Km-value for NADPH is below 0.001 mM, pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Ignisphaera aggregans | |
1.1.1.383 | 0.024 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Metallosphaera sedula | |
1.1.1.383 | 0.031 | - |
NADPH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Metallosphaera sedula | |
1.1.1.383 | 0.039 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Hydrogenobaculum sp. Y04AAS1 | |
1.1.1.383 | 0.046 | - |
NADPH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Hydrogenobaculum sp. Y04AAS1 |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.382 | Archaeoglobus fulgidus | O28294 | - |
- |
1.1.1.382 | Desulfosudis oleivorans | - |
- |
- |
1.1.1.382 | Thermacetogenium phaeum | - |
- |
- |
1.1.1.382 | uncultured archaeon | - |
- |
- |
1.1.1.383 | Hydrogenobaculum sp. Y04AAS1 | - |
- |
- |
1.1.1.383 | Ignisphaera aggregans | - |
- |
- |
1.1.1.383 | Metallosphaera sedula | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.382 | - |
Thermacetogenium phaeum |
1.1.1.382 | - |
uncultured archaeon |
1.1.1.382 | - |
Desulfosudis oleivorans |
1.1.1.382 | - |
Archaeoglobus fulgidus |
1.1.1.383 | - |
Metallosphaera sedula |
1.1.1.383 | - |
Hydrogenobaculum sp. Y04AAS1 |
1.1.1.383 | - |
Ignisphaera aggregans |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.382 | (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADH + H+ | (2S)-2-hydroxy-2-methyl-3-oxobutanoate i.e. (2S)-2-acetolactate | Thermacetogenium phaeum | (2R)-2,3-dihydroxy-3-methylbutanoate + NAD+ | - |
? | |
1.1.1.382 | (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADH + H+ | (2S)-2-hydroxy-2-methyl-3-oxobutanoate i.e. (2S)-2-acetolactate | uncultured archaeon | (2R)-2,3-dihydroxy-3-methylbutanoate + NAD+ | - |
? | |
1.1.1.382 | (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADH + H+ | (2S)-2-hydroxy-2-methyl-3-oxobutanoate i.e. (2S)-2-acetolactate | Desulfosudis oleivorans | (2R)-2,3-dihydroxy-3-methylbutanoate + NAD+ | - |
? | |
1.1.1.382 | (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADH + H+ | (2S)-2-hydroxy-2-methyl-3-oxobutanoate i.e. (2S)-2-acetolactate | Archaeoglobus fulgidus | (2R)-2,3-dihydroxy-3-methylbutanoate + NAD+ | - |
? | |
1.1.1.383 | (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADH + H+ | (2S)-2-hydroxy-2-methyl-3-oxobutanoate i.e. (2S)-2-acetolactate | Metallosphaera sedula | (2R)-2,3-dihydroxy-3-methylbutanoate + NAD+ | - |
? | |
1.1.1.383 | (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADH + H+ | (2S)-2-hydroxy-2-methyl-3-oxobutanoate i.e. (2S)-2-acetolactate | Hydrogenobaculum sp. Y04AAS1 | (2R)-2,3-dihydroxy-3-methylbutanoate + NAD+ | - |
? | |
1.1.1.383 | (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADH + H+ | (2S)-2-hydroxy-2-methyl-3-oxobutanoate i.e. (2S)-2-acetolactate | Ignisphaera aggregans | (2R)-2,3-dihydroxy-3-methylbutanoate + NAD+ | - |
? | |
1.1.1.383 | (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+ | (2S)-2-hydroxy-2-methyl-3-oxobutanoate i.e. (2S)-2-acetolactate | Metallosphaera sedula | (2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ | - |
? | |
1.1.1.383 | (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+ | (2S)-2-hydroxy-2-methyl-3-oxobutanoate i.e. (2S)-2-acetolactate | Hydrogenobaculum sp. Y04AAS1 | (2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ | - |
? | |
1.1.1.383 | (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+ | (2S)-2-hydroxy-2-methyl-3-oxobutanoate i.e. (2S)-2-acetolactate | Ignisphaera aggregans | (2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.382 | 0.1 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Archaeoglobus fulgidus | |
1.1.1.382 | 0.22 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | uncultured archaeon | |
1.1.1.382 | 0.25 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Desulfosudis oleivorans | |
1.1.1.382 | 0.46 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Thermacetogenium phaeum | |
1.1.1.383 | 0.02 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Ignisphaera aggregans | |
1.1.1.383 | 0.03 | - |
NADPH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Ignisphaera aggregans | |
1.1.1.383 | 0.06 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Metallosphaera sedula | |
1.1.1.383 | 0.07 | - |
NADPH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Metallosphaera sedula | |
1.1.1.383 | 0.12 | - |
NADPH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Hydrogenobaculum sp. Y04AAS1 | |
1.1.1.383 | 0.12 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Hydrogenobaculum sp. Y04AAS1 |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.382 | 7 | - |
assay at | Thermacetogenium phaeum |
1.1.1.382 | 7 | - |
assay at | uncultured archaeon |
1.1.1.382 | 7 | - |
assay at | Desulfosudis oleivorans |
1.1.1.382 | 7 | - |
assay at | Archaeoglobus fulgidus |
1.1.1.383 | 7 | - |
assay at | Metallosphaera sedula |
1.1.1.383 | 7 | - |
assay at | Hydrogenobaculum sp. Y04AAS1 |
1.1.1.383 | 7 | - |
assay at | Ignisphaera aggregans |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.382 | NADH | specific for NADH. NADH/NADPH ratio of kcat/Km is 13 | Archaeoglobus fulgidus | |
1.1.1.382 | NADH | specific for NADH. NADH/NADPH ratio of kcat/Km is 152 | uncultured archaeon | |
1.1.1.382 | NADH | specific for NADH. NADH/NADPH ratio of kcat/Km is 74 | Thermacetogenium phaeum | |
1.1.1.382 | NADH | specific for NADH. No activity with NADPH | Desulfosudis oleivorans | |
1.1.1.383 | NADH | the enzyme can use both NADH and NADPH with similar efficiency | Metallosphaera sedula | |
1.1.1.383 | NADH | the enzyme can use both NADH and NADPH with similar efficiency | Hydrogenobaculum sp. Y04AAS1 | |
1.1.1.383 | NADH | the enzyme can use both NADH and NADPH with similar efficiency | Ignisphaera aggregans | |
1.1.1.383 | NADPH | the enzyme can use both NADH and NADPH with similar efficiency | Metallosphaera sedula | |
1.1.1.383 | NADPH | the enzyme can use both NADH and NADPH with similar efficiency | Hydrogenobaculum sp. Y04AAS1 | |
1.1.1.383 | NADPH | the enzyme can use both NADH and NADPH with similar efficiency | Ignisphaera aggregans |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.382 | additional information | - |
NADH | kcat/Km for NADH is at least 460 /mM*s, pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Thermacetogenium phaeum | |
1.1.1.382 | 8 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Desulfosudis oleivorans | |
1.1.1.382 | 20 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Archaeoglobus fulgidus | |
1.1.1.382 | 200 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | uncultured archaeon | |
1.1.1.383 | additional information | - |
NADH | kcat/Km-value for NADH is above 20/mM*s, pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Ignisphaera aggregans | |
1.1.1.383 | additional information | - |
NADPH | kcat/Km-value for NADPH is above 25/mM*s, pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Ignisphaera aggregans | |
1.1.1.383 | 2.1 | - |
NADPH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Metallosphaera sedula | |
1.1.1.383 | 2.5 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Metallosphaera sedula | |
1.1.1.383 | 2.7 | - |
NADPH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Hydrogenobaculum sp. Y04AAS1 | |
1.1.1.383 | 3.2 | - |
NADH | pH 7, temperature not specified in the publication, cosubstrate: (2S)-2-hydroxy-2-methyl-3-oxobutanoate | Hydrogenobaculum sp. Y04AAS1 |