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Literature summary extracted from
- Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme (2013), J. Med. Chem., 56, 7527-7535.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 3.4.17.2 | crystal structures of selenium-, sulfur-, and phosphinic acid containing inhibitors bound to porcine pancreatic carboxypeptidase B are determined at 1.7, 2.15 and 1.9 A, respectively | Sus scrofa |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.17.2 | (2S)-7-amino-2-[(hydroxy[(1R)-2-methyl-1-[(3-phenylpropanoyl)amino]propyl]phosphoryl)methyl]heptanoic acid | - |
Sus scrofa |  |
| 3.4.17.2 | 3-(6-amino-5-chloropyridin-3-yl)-2-(selanylmethyl)propanoic acid | - |
Sus scrofa | |
| 3.4.17.2 | 7-amino-2-(selanylmethyl)heptanoic acid | - |
Sus scrofa | |
| 3.4.17.2 | 7-amino-2-(sulfanylmethyl)heptanoic acid | - |
Sus scrofa | |
| 3.4.17.2 | 7-amino-2-[(propanoylselanyl)methyl]heptanoic acid | - |
Sus scrofa | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.17.2 | Sus scrofa | P09955 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.17.2 | using affinity chromatography and gel filtration | Sus scrofa |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.17.2 | carboxypeptidase B | - |
Sus scrofa |
| 3.4.17.2 | ppCPB | - |
Sus scrofa |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.17.2 | 0.000000025 | - |
pH and temperature not specified in the publication | Sus scrofa | 3-(6-amino-5-chloropyridin-3-yl)-2-(selanylmethyl)propanoic acid | |
| 3.4.17.2 | 0.0000011 | - |
pH and temperature not specified in the publication | Sus scrofa | 7-amino-2-[(propanoylselanyl)methyl]heptanoic acid | |
| 3.4.17.2 | 0.000002 | - |
pH and temperature not specified in the publication | Sus scrofa | 7-amino-2-(selanylmethyl)heptanoic acid | |
| 3.4.17.2 | 0.0000055 | - |
pH and temperature not specified in the publication | Sus scrofa | (2S)-7-amino-2-[(hydroxy[(1R)-2-methyl-1-[(3-phenylpropanoyl)amino]propyl]phosphoryl)methyl]heptanoic acid | |
| 3.4.17.2 | 0.000034 | - |
pH and temperature not specified in the publication | Sus scrofa | 7-amino-2-(sulfanylmethyl)heptanoic acid | |
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