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Literature summary extracted from
- Effect of zinc and calcium ions on the rat kidney membrane-bound form of dipeptidyl peptidase IV (2013), J. Biosci., 38, 461-469.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.14.5 | bacitracin | competitive | Rattus norvegicus |  |
| 3.4.14.5 | bestatin | competitive | Rattus norvegicus | |
| 3.4.14.5 | Ca2+ | mixed type inhibition, Ca2+ ions preferentially bind to the betA-propeller domain | Rattus norvegicus | |
| 3.4.14.5 | L-threo-Ile-thiazolidide | - |
Rattus norvegicus | |
| 3.4.14.5 | TLCK | irreversble | Rattus norvegicus | |
| 3.4.14.5 | Zn2+ | mixed type inhibition | Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.14.5 | 0.076 | - |
Gly-L-Pro-4-nitroanilide | pH 8.0, 37°C | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.14.5 | membrane | - |
Rattus norvegicus | 16020 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.14.5 | 260000 | - |
gel filtration | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.14.5 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.14.5 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.14.5 | kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.14.5 | Gly-L-Pro-4-nitroanilide + H2O | - |
Rattus norvegicus | Gly-L-Pro + 4-nitroaniline | - |
? | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.14.5 | 0.000064 | - |
L-threo-Ile-thiazolidide | pH 8.0, 37°C | Rattus norvegicus | |
| 3.4.14.5 | 0.16 | - |
bacitracin | pH 8.0, 37°C | Rattus norvegicus | |
| 3.4.14.5 | 0.23 | - |
bestatin | pH 8.0, 37°C | Rattus norvegicus | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.14.5 | 1.2 | - |
pH 8.0, 37°C | Rattus norvegicus | TLCK | |
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Release 2023.1 (January 2023)
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