EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.34 | factor XIIa | - |
Mus musculus | |
3.4.21.34 | factor XIIa | - |
Rattus norvegicus | |
3.4.21.34 | factor XIIa | - |
Macaca fascicularis | |
3.4.21.34 | factor XIIa | - |
Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.4.21.34 | in complex with human IgG1 monoclonal antibody DX-2930, hanging drop vapor diffusion method, using 0.1 M Bis-Tris, pH 6.5, 20% (w/v) PEG 5000 MME | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.34 | C1-inhibitor | - |
Homo sapiens | |
3.4.21.34 | C1-inhibitor | - |
Macaca fascicularis | |
3.4.21.34 | C1-inhibitor | - |
Mus musculus | |
3.4.21.34 | C1-inhibitor | - |
Rattus norvegicus | |
3.4.21.34 | human IgG1 monoclonal antibody DX-2930 | potently and specifically inhibits plasma kallikrein | Homo sapiens | |
3.4.21.34 | human IgG1 monoclonal antibody DX-2930 | potently and specifically inhibits plasma kallikrein | Macaca fascicularis | |
3.4.21.34 | human IgG1 monoclonal antibody DX-2930 | potently and specifically inhibits plasma kallikrein | Mus musculus | |
3.4.21.34 | human IgG1 monoclonal antibody DX-2930 | potently and specifically inhibits plasma kallikrein | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.34 | kininogen + H2O | Mus musculus | - |
bradykinin + fragments of kininogen | - |
? | |
3.4.21.34 | kininogen + H2O | Rattus norvegicus | - |
bradykinin + fragments of kininogen | - |
? | |
3.4.21.34 | kininogen + H2O | Macaca fascicularis | - |
bradykinin + fragments of kininogen | - |
? | |
3.4.21.34 | kininogen + H2O | Homo sapiens | - |
bradykinin + fragments of kininogen | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.34 | Homo sapiens | P03952 | - |
- |
3.4.21.34 | Macaca fascicularis | - |
- |
- |
3.4.21.34 | Mus musculus | - |
- |
- |
3.4.21.34 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.34 | blood plasma | - |
Mus musculus | - |
3.4.21.34 | blood plasma | - |
Rattus norvegicus | - |
3.4.21.34 | blood plasma | - |
Macaca fascicularis | - |
3.4.21.34 | blood plasma | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.34 | kininogen + H2O | - |
Mus musculus | bradykinin + fragments of kininogen | - |
? | |
3.4.21.34 | kininogen + H2O | - |
Rattus norvegicus | bradykinin + fragments of kininogen | - |
? | |
3.4.21.34 | kininogen + H2O | - |
Macaca fascicularis | bradykinin + fragments of kininogen | - |
? | |
3.4.21.34 | kininogen + H2O | - |
Homo sapiens | bradykinin + fragments of kininogen | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.34 | PKal | - |
Mus musculus |
3.4.21.34 | PKal | - |
Rattus norvegicus |
3.4.21.34 | PKal | - |
Macaca fascicularis |
3.4.21.34 | PKal | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.34 | 0.00000007 | - |
human IgG1 monoclonal antibody DX-2930 | at pH 7.5 and 30°C | Macaca fascicularis | |
3.4.21.34 | 0.00000012 | - |
human IgG1 monoclonal antibody DX-2930 | at pH 7.5 and 30°C | Homo sapiens | |
3.4.21.34 | 0.00000017 | - |
human IgG1 monoclonal antibody DX-2930 | at pH 7.5 and 30°C | Mus musculus | |
3.4.21.34 | 0.00000017 | - |
human IgG1 monoclonal antibody DX-2930 | at pH 7.5 and 30°C | Rattus norvegicus |