Literature summary extracted from

Kenniston, J.; Faucette, R.; Martik, D.; Comeau, S.; Lindberg, A.; Kopacz, K.; Conley, G.; Chen, J.; Viswanathan, M.; Kastrapeli, N.; Cosic, J.; Mason, S.; DiLeo, M.; Abendroth, J.; Kuzmic, P.; Ladner, R.; Edwards, T.; TenHoor, C.; Adelman, B.; Nixon, A.;
Inhibition of plasma kallikrein by a highly specific active site blocking antibody (2014), J. Biol. Chem., 289, 23596-23608.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.21.34	factor XIIa	-	Mus musculus
3.4.21.34	factor XIIa	-	Rattus norvegicus
3.4.21.34	factor XIIa	-	Macaca fascicularis
3.4.21.34	factor XIIa	-	Homo sapiens

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
3.4.21.34	in complex with human IgG1 monoclonal antibody DX-2930, hanging drop vapor diffusion method, using 0.1 M Bis-Tris, pH 6.5, 20% (w/v) PEG 5000 MME	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.34	C1-inhibitor	-	Homo sapiens
3.4.21.34	C1-inhibitor	-	Macaca fascicularis
3.4.21.34	C1-inhibitor	-	Mus musculus
3.4.21.34	C1-inhibitor	-	Rattus norvegicus
3.4.21.34	human IgG1 monoclonal antibody DX-2930	potently and specifically inhibits plasma kallikrein	Homo sapiens
3.4.21.34	human IgG1 monoclonal antibody DX-2930	potently and specifically inhibits plasma kallikrein	Macaca fascicularis
3.4.21.34	human IgG1 monoclonal antibody DX-2930	potently and specifically inhibits plasma kallikrein	Mus musculus
3.4.21.34	human IgG1 monoclonal antibody DX-2930	potently and specifically inhibits plasma kallikrein	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.21.34	kininogen + H2O	Mus musculus	-	bradykinin + fragments of kininogen	-	?
3.4.21.34	kininogen + H2O	Rattus norvegicus	-	bradykinin + fragments of kininogen	-	?
3.4.21.34	kininogen + H2O	Macaca fascicularis	-	bradykinin + fragments of kininogen	-	?
3.4.21.34	kininogen + H2O	Homo sapiens	-	bradykinin + fragments of kininogen	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.34	Homo sapiens	P03952	-	-
3.4.21.34	Macaca fascicularis	-	-	-
3.4.21.34	Mus musculus	-	-	-
3.4.21.34	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.34	blood plasma	-	Mus musculus	-
3.4.21.34	blood plasma	-	Rattus norvegicus	-
3.4.21.34	blood plasma	-	Macaca fascicularis	-
3.4.21.34	blood plasma	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.34	kininogen + H2O	-	Mus musculus	bradykinin + fragments of kininogen	-	?
3.4.21.34	kininogen + H2O	-	Rattus norvegicus	bradykinin + fragments of kininogen	-	?
3.4.21.34	kininogen + H2O	-	Macaca fascicularis	bradykinin + fragments of kininogen	-	?
3.4.21.34	kininogen + H2O	-	Homo sapiens	bradykinin + fragments of kininogen	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.34	PKal	-	Mus musculus
3.4.21.34	PKal	-	Rattus norvegicus
3.4.21.34	PKal	-	Macaca fascicularis
3.4.21.34	PKal	-	Homo sapiens

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
3.4.21.34	0.00000007	-	human IgG1 monoclonal antibody DX-2930	at pH 7.5 and 30°C	Macaca fascicularis
3.4.21.34	0.00000012	-	human IgG1 monoclonal antibody DX-2930	at pH 7.5 and 30°C	Homo sapiens
3.4.21.34	0.00000017	-	human IgG1 monoclonal antibody DX-2930	at pH 7.5 and 30°C	Mus musculus
3.4.21.34	0.00000017	-	human IgG1 monoclonal antibody DX-2930	at pH 7.5 and 30°C	Rattus norvegicus

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Release 2023.1 (January 2023)