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Literature summary extracted from

  • Unciti-Broceta, J.D.; Maceira, J.; Morales, S.; Garcia-Perez, A.; Munoz-Torres, M.E.; Garcia-Salcedo, J.A.
    Nicotinamide inhibits the lysosomal cathepsin B-like protease and kills African trypanosomes (2013), J. Biol. Chem., 288, 10548-10557.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.B6 recombinant expression in Pichia pastoris Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.B6 nicotinamide complete inhibition at 25 mM Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.B6 lysosome
-
Trypanosoma brucei 5764
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.B6 42000
-
x * 42000, recombinant zymogen, SDS-PAGE Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.B6 Trypanosoma brucei Q6R7Z5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.B6 Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
Trypanosoma brucei Z-Arg-Arg + 7-amino-4-methylcoumarin
-
?

Subunits

EC Number Subunits Comment Organism
3.4.22.B6 ? x * 42000, recombinant zymogen, SDS-PAGE Trypanosoma brucei

Synonyms

EC Number Synonyms Comment Organism
3.4.22.B6 CatB
-
Trypanosoma brucei

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.B6 37
-
assay at Trypanosoma brucei

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.B6 6
-
assay at Trypanosoma brucei

General Information

EC Number General Information Comment Organism
3.4.22.B6 malfunction inhibition of the lysosomal cathepsin B-like protease blocks endocytosis causing cell death. Nicotinamide causes cytokinesis defects and cell cycle arrest at G2 phase Trypanosoma brucei
3.4.22.B6 physiological function cathepsin B-like is a lysosomal protease responsible for degradation of host-derived growth factors, such as transferrin, in the bloodstream form of Trypanosoma brucei Trypanosoma brucei