Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chander, P.; Gentleman, S.; Poliakov, E.; Redmond, T.
    Aromatic residues in the substrate cleft of RPE65 protein govern retinol isomerization and modulate its progression (2012), J. Biol. Chem., 287, 30552-30559.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.90 F103I mutant produces reduced amounts of 13-cis-retinol and reduced production of 11-cis-retinol compared to wild-type Mus musculus
3.1.1.90 F103L mutant produces increased amounts of 13-cis-retinol but reduced production of 11-cis-retinol compared to wild-type Mus musculus
3.1.1.90 F103W mutant produces reduced amounts of 13-cis-retinol and reduced production of 11-cis-retinol compared to wild-type Mus musculus
3.1.1.90 F103Y mutant produces reduced amounts of 13-cis-retinol and reduced production of 11-cis-retinol compared to wild-type Mus musculus
3.1.1.90 F312L mutant shows severly impaired enzymatic activity Mus musculus
3.1.1.90 F312W mutant shows severly impaired enzymatic activity Mus musculus
3.1.1.90 F312Y mutant shows severly impaired enzymatic activity Mus musculus
3.1.1.90 F418A mutant shows severly impaired enzymatic activity Mus musculus
3.1.1.90 F418L mutant shows severly impaired enzymatic activity Mus musculus
3.1.1.90 F418W mutant shows severly impaired enzymatic activity Mus musculus
3.1.1.90 F418Y mutant shows severly impaired enzymatic activity Mus musculus
3.1.1.90 F526A mutant shows a increased production level of 13-cis-retinol compared to wild-type Mus musculus
3.1.1.90 F526L mutant shows a decreased production level of 11-cis-retinol compared to wild-type Mus musculus
3.1.1.90 F526W mutant shows a decreased production level of 11-cis-retinol compared to wild-type Mus musculus
3.1.1.90 F526Y mutant shows a decreased production level of 11-cis-retinol compared to wild-type Mus musculus
3.1.1.90 F61A mutant shows severly impaired enzymatic activity Mus musculus
3.1.1.90 F61L mutant shows severly impaired enzymatic activity Mus musculus
3.1.1.90 F61W mutant shows severly impaired enzymatic activity Mus musculus
3.1.1.90 F61Y mutant shows severly impaired enzymatic activity Mus musculus
3.1.1.90 Y338A mutant produces increased amounts of 13-cis-retinol but reduced production of 11-cis-retinol compared to wild-type Mus musculus
3.1.1.90 Y338F mutant produces similar amounts of 13-cis-retinol but reduced production of 11-cis-retinol compared to wild-type Mus musculus
3.1.1.90 Y338L mutant produces similar amounts of 13-cis-retinol but reduced production of 11-cis-retinol compared to wild-type Mus musculus
3.1.1.90 Y338W mutant produces similar amounts of 13-cis-retinol but reduced production of 11-cis-retinol compared to wild-type Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.90 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.90 all-trans retinyl ester + H2O
-
Mus musculus 13-cis retinol + ?
-
?
3.1.1.90 all-trans retinyl ester + H2O
-
Mus musculus 11-cis retinol + ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.90 Rpe65
-
Mus musculus