EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.21.89 | K174A | mutation is lethal | Mycobacterium tuberculosis |
3.4.21.89 | S94A | mutation is lethal | Mycobacterium tuberculosis |
3.4.21.89 | S96A | mutation is lethal | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.89 | 1-(2,5-dichlorophenyl)-3-(dimethylamino)propan-1-one | overexpression of lepB reduces the susceptibility of Mycobacterium tuberculosis to 1-(2,5-dichlorophenyl)-3-(dimethylamino)propan-1-one, and downregulation results in increased susceptibility. Treatment with 1-(2,5-dichlorophenyl)-3-(dimethylamino)propan-1-one leads to a rapid loss of viability and cell lysis. The compound has increased potency in nonreplicating cells, causing a reduction in viable cell numbers below the detection limit after 24 h | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.89 | Mycobacterium tuberculosis | P9WKA1 | - |
- |
3.4.21.89 | Mycobacterium tuberculosis H37Rv | P9WKA1 | - |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.89 | LepB | - |
Mycobacterium tuberculosis |
3.4.21.89 | Rv2903c | - |
Mycobacterium tuberculosis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.21.89 | physiological function | gene is essential, and reduced lepB expression is detrimental to growth | Mycobacterium tuberculosis |