Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ollinger, J.; OMalley, T.; Ahn, J.; Odingo, J.; Parish, T.
    Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions (2012), J. Bacteriol., 194, 2614-2619.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.89 K174A mutation is lethal Mycobacterium tuberculosis
3.4.21.89 S94A mutation is lethal Mycobacterium tuberculosis
3.4.21.89 S96A mutation is lethal Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.89 1-(2,5-dichlorophenyl)-3-(dimethylamino)propan-1-one overexpression of lepB reduces the susceptibility of Mycobacterium tuberculosis to 1-(2,5-dichlorophenyl)-3-(dimethylamino)propan-1-one, and downregulation results in increased susceptibility. Treatment with 1-(2,5-dichlorophenyl)-3-(dimethylamino)propan-1-one leads to a rapid loss of viability and cell lysis. The compound has increased potency in nonreplicating cells, causing a reduction in viable cell numbers below the detection limit after 24 h Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.89 Mycobacterium tuberculosis P9WKA1
-
-
3.4.21.89 Mycobacterium tuberculosis H37Rv P9WKA1
-
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.89 LepB
-
Mycobacterium tuberculosis
3.4.21.89 Rv2903c
-
Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
3.4.21.89 physiological function gene is essential, and reduced lepB expression is detrimental to growth Mycobacterium tuberculosis