EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.1 | 2-chlorobenzohydrazide | competitive inhibition | Capra hircus | |
3.4.22.1 | 2-methoxybenzohydrazide | competitive inhibition | Capra hircus | |
3.4.22.1 | 3,5-diphenyl-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.1 | 3-(2-hydroxy-3-methylphenyl)-5-(2-hydroxy-3-methylphenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.1 | 3-(2-methylphenyl)-5-(2-methylphenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.1 | 3-(3-aminophenyl)-5-(3-aminophenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.1 | 3-(3-methylphenyl)-5-(3-methylphenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.1 | 3-(4-chlorophenyl)-5-(4-chlorophenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.1 | 3-(4-methylphenyl)-5-(4-methylphenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.1 | 3-phenyl-5-(3-nitrophenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.1 | 3-phenyl-5-(4-nitrophenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.1 | 4-hydroxybenzohydrazide | competitive inhibition | Capra hircus | |
3.4.22.1 | 4-methoxybenzohydrazide | competitive inhibition | Capra hircus | |
3.4.22.1 | phenylacetyl hydrazine | competitive inhibition | Capra hircus | |
3.4.22.16 | 2-chlorobenzohydrazide | non-competitive inhibition; non-competitive inhibition, 89.46% residual activity at 0.01 mM | Capra hircus | |
3.4.22.16 | 2-methoxybenzohydrazide | non-competitive inhibition; non-competitive inhibition, 97.83% residual activity at 0.01 mM | Capra hircus | |
3.4.22.16 | 3,5-diphenyl-4-amino-1,2,4-triazole | non-competitive inhibition; non-competitive inhibition, 69.73% residual activity at 0.01 mM | Capra hircus | |
3.4.22.16 | 3-(2'-hydroxy-3'-methylphenyl)-5-(2'-hydroxy-3'-methylphenyl)-4-amino-1,2,4-triazole | non-competitive inhibition, 88.11% residual activity at 0.01 mM | Capra hircus | |
3.4.22.16 | 3-(2'-methylphenyl)-5-(2'-methylphenyl)-4-amino-1,2,4-triazole | non-competitive inhibition, 82.97% residual activity at 0.01 mM | Capra hircus | |
3.4.22.16 | 3-(2-hydroxy-3-methylphenyl)-5-(2-hydroxy-3-methylphenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.16 | 3-(2-methylphenyl)-5-(2-methylphenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.16 | 3-(3'-aminophenyl)-5-(3'-aminophenyl)-4-amino-1,2,4-triazole | non-competitive inhibition, 16.37% residual activity at 0.01 mM | Capra hircus | |
3.4.22.16 | 3-(3'-methylphenyl)-5-(3'-methylphenyl)-4-amino-1,2,4-triazole | non-competitive inhibition, 79.45% residual activity at 0.01 mM | Capra hircus | |
3.4.22.16 | 3-(3'-nitrophenyl)-5-(3'-nitrophenyl)-4-amino-1,2,4-triazole | non-competitive inhibition, 45.13% residual activity at 0.01 mM | Capra hircus | |
3.4.22.16 | 3-(3-aminophenyl)-5-(3-aminophenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.16 | 3-(3-methylphenyl)-5-(3-methylphenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.16 | 3-(4'-chlorophenyl)-5-(4'-chlorophenyl)-4-amino-1,2,4-triazole | non-competitive inhibition, 24.35% residual activity at 0.01 mM | Capra hircus | |
3.4.22.16 | 3-(4'-methylphenyl)-5-(4'-methylphenyl)-4-amino-1,2,4-triazole | non-competitive inhibition, 89.46% residual activity at 0.01 mM | Capra hircus | |
3.4.22.16 | 3-(4-chlorophenyl)-5-(4-chlorophenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.16 | 3-(4-methylphenyl)-5-(4-methylphenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.16 | 3-phenyl-5-(3-nitrophenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.16 | 3-phenyl-5-(4'-nitrophenyl)-4-amino-1,2,4-triazole | non-competitive inhibition, 78.11% residual activity at 0.01 mM | Capra hircus | |
3.4.22.16 | 3-phenyl-5-(4-nitrophenyl)-4-amino-1,2,4-triazole | non-competitive inhibition | Capra hircus | |
3.4.22.16 | 4-hydroxybenzohydrazide | non-competitive inhibition; non-competitive inhibition, 91.62% residual activity at 0.01 mM | Capra hircus | |
3.4.22.16 | 4-methoxybenzohydrazide | non-competitive inhibition; non-competitive inhibition, 45% residual activity at 0.01 mM | Capra hircus | |
3.4.22.16 | Leu-CH2-Cl | complete inhibition at 0.01 mM | Capra hircus | |
3.4.22.16 | leupeptin | complete inhibition at 0.01 mM | Capra hircus | |
3.4.22.16 | phenylacetyl hydrazine | non-competitive inhibition; non-competitive inhibition, 81.08% residual activity at 0.01 mM | Capra hircus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.1 | Capra hircus | H9B8T9 | - |
- |
3.4.22.16 | Capra hircus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.22.1 | liver | - |
Capra hircus | - |
3.4.22.16 | liver | - |
Capra hircus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.4.22.1 | 0.01038 | - |
pH 5, 37°C | Capra hircus |
3.4.22.16 | 0.02256 | - |
pH 5, 37°C | Capra hircus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.1 | N-benzoyl-L-Arg-2-naphthylamide + H2O | - |
Capra hircus | N-benzoyl-L-Arg + 2-naphthylamine | - |
? | |
3.4.22.16 | L-Leu-2-naphthylamide + H2O | - |
Capra hircus | L-Leu + 2-naphthylamine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.22.1 | cathepsin B | - |
Capra hircus |
3.4.22.16 | cathepsin H | - |
Capra hircus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.22.1 | 37 | - |
assay at | Capra hircus |
3.4.22.16 | 37 | - |
assay at | Capra hircus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.22.1 | 5 | - |
assay at | Capra hircus |
3.4.22.16 | 5 | - |
assay at | Capra hircus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.22.1 | 0.00064 | - |
4-methoxybenzohydrazide | pH 5, 37°C | Capra hircus | |
3.4.22.1 | 0.00087 | - |
phenylacetyl hydrazine | pH 5, 37°C | Capra hircus | |
3.4.22.1 | 0.00095 | - |
3-(3-aminophenyl)-5-(3-aminophenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.1 | 0.00136 | - |
2-chlorobenzohydrazide | pH 5, 37°C | Capra hircus | |
3.4.22.1 | 0.00143 | - |
3-phenyl-5-(3-nitrophenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.1 | 0.0019 | - |
4-hydroxybenzohydrazide | pH 5, 37°C | Capra hircus | |
3.4.22.1 | 0.0024 | - |
3-(4-chlorophenyl)-5-(4-chlorophenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.1 | 0.0032 | - |
3-(2-hydroxy-3-methylphenyl)-5-(2-hydroxy-3-methylphenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.1 | 0.0048 | - |
3-phenyl-5-(4-nitrophenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.1 | 0.008 | - |
3-(4-methylphenyl)-5-(4-methylphenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.1 | 0.0127 | - |
2-methoxybenzohydrazide | pH 5, 37°C | Capra hircus | |
3.4.22.1 | 0.0149 | - |
3-(2-methylphenyl)-5-(2-methylphenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.1 | 0.0385 | - |
3-(3-methylphenyl)-5-(3-methylphenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.1 | 0.1205 | - |
3,5-diphenyl-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.16 | 0.002 | - |
3-(3'-aminophenyl)-5-(3'-aminophenyl)-4-amino-1,2,4-triazole | at pH 7.0 and 37°C | Capra hircus | |
3.4.22.16 | 0.002 | - |
3-(3-aminophenyl)-5-(3-aminophenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.16 | 0.0033 | - |
3-(4'-chlorophenyl)-5-(4'-chlorophenyl)-4-amino-1,2,4-triazole | at pH 7.0 and 37°C | Capra hircus | |
3.4.22.16 | 0.0033 | - |
3-(4-chlorophenyl)-5-(4-chlorophenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.16 | 0.0082 | - |
4-methoxybenzohydrazide | at pH 7.0 and 37°C | Capra hircus | |
3.4.22.16 | 0.0082 | - |
4-methoxybenzohydrazide | pH 5, 37°C | Capra hircus | |
3.4.22.16 | 0.0086 | - |
3-(3'-nitrophenyl)-5-(3'-nitrophenyl)-4-amino-1,2,4-triazole | at pH 7.0 and 37°C | Capra hircus | |
3.4.22.16 | 0.0086 | - |
3-phenyl-5-(3-nitrophenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.16 | 0.0232 | - |
3,5-diphenyl-4-amino-1,2,4-triazole | at pH 7.0 and 37°C | Capra hircus | |
3.4.22.16 | 0.0232 | - |
3,5-diphenyl-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.16 | 0.0364 | - |
3-phenyl-5-(4'-nitrophenyl)-4-amino-1,2,4-triazole | at pH 7.0 and 37°C | Capra hircus | |
3.4.22.16 | 0.0364 | - |
3-phenyl-5-(4-nitrophenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.16 | 0.0387 | - |
3-(3'-methylphenyl)-5-(3'-methylphenyl)-4-amino-1,2,4-triazole | at pH 7.0 and 37°C | Capra hircus | |
3.4.22.16 | 0.0387 | - |
3-(3-methylphenyl)-5-(3-methylphenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.16 | 0.0425 | - |
phenylacetyl hydrazine | at pH 7.0 and 37°C | Capra hircus | |
3.4.22.16 | 0.0425 | - |
phenylacetyl hydrazine | pH 5, 37°C | Capra hircus | |
3.4.22.16 | 0.0532 | - |
3-(2'-methylphenyl)-5-(2'-methylphenyl)-4-amino-1,2,4-triazole | at pH 7.0 and 37°C | Capra hircus | |
3.4.22.16 | 0.0532 | - |
3-(2-methylphenyl)-5-(2-methylphenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.16 | 0.0781 | - |
3-(2'-hydroxy-3'-methylphenyl)-5-(2'-hydroxy-3'-methylphenyl)-4-amino-1,2,4-triazole | at pH 7.0 and 37°C | Capra hircus | |
3.4.22.16 | 0.0781 | - |
3-(2-hydroxy-3-methylphenyl)-5-(2-hydroxy-3-methylphenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.16 | 0.0901 | - |
2-chlorobenzohydrazide | at pH 7.0 and 37°C | Capra hircus | |
3.4.22.16 | 0.0901 | - |
3-(4'-methylphenyl)-5-(4'-methylphenyl)-4-amino-1,2,4-triazole | at pH 7.0 and 37°C | Capra hircus | |
3.4.22.16 | 0.0901 | - |
2-chlorobenzohydrazide | pH 5, 37°C | Capra hircus | |
3.4.22.16 | 0.0901 | - |
3-(4-methylphenyl)-5-(4-methylphenyl)-4-amino-1,2,4-triazole | pH 5, 37°C | Capra hircus | |
3.4.22.16 | 0.1123 | - |
4-hydroxybenzohydrazide | at pH 7.0 and 37°C | Capra hircus | |
3.4.22.16 | 0.1123 | - |
4-hydroxybenzohydrazide | pH 5, 37°C | Capra hircus | |
3.4.22.16 | 0.588 | - |
2-methoxybenzohydrazide | at pH 7.0 and 37°C | Capra hircus | |
3.4.22.16 | 0.588 | - |
2-methoxybenzohydrazide | pH 5, 37°C | Capra hircus |