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Literature summary extracted from

  • Seremwe, M.; Schnellmann, R.G.; Bollag, W.B.
    Calpain-10 activity underlies angiotensin II-induced aldosterone production in an adrenal glomerulosa cell model (2015), Endocrinology, 156, 2138-2149.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.B30 angiotensin II activates the enzyme in vivo, reduced by pan-calpain inhibitors Homo sapiens

Application

EC Number Application Comment Organism
3.4.22.B30 medicine the enzyme is a potential target for the development of drug therapies for the treatment of hypertension Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.B30 additional information siRNA-mediated knockdown of calpain-10 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.B30 additional information pan-calpain inhibitors reduce AngII-induced aldosterone production in 2 adrenal glomerulosa cell models, primary bovine zona glomerulosa and human adrenocortical carcinoma cells Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.22.B30 Ca2+ dependent on Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.B30 Homo sapiens Q9HC96
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.B30 adrenal glomerulosa cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.22.B30 calpain-10
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.22.B30 malfunction siRNA-mediated knockdown of calpain-10 inhibits aldosterone production and CYP11B2 expression, whereas adenovirus-mediated overexpression of calpain-10 results in increased AngII-induced aldosterone production Homo sapiens
3.4.22.B30 physiological function calpain-10 activity underlies angiotensin II-induced aldosterone production in an adrenal glomerulosa cell model Homo sapiens