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Literature summary extracted from

  • Smith, M.A.; Cross, A.R.; Jones, O.T.; Griffiths, W.T.; Stymne, S.; Stobart, K.
    Electron-transport components of the 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine DELTA 12-desaturase (DELTA12-desaturase) in microsomal preparations from developing safflower (Carthamus tinctorius L.) cotyledons (1990), Biochem. J., 272, 23-29.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.22 8-hydroxyquinoline 76% residual activity at 1 mM Carthamus tinctorius
1.14.19.22 CN- 15% residual activity at 1 mM Carthamus tinctorius
1.14.19.22 cyanide
-
 Carthamus tinctorius
1.14.19.22 additional information not affected by CO and 2,2'-bipyridyl Carthamus tinctorius
1.14.19.22 mycobactin 81% residual activity at 1 mM Carthamus tinctorius
1.14.19.22 o-phenanthroline 83% residual activity at 1 mM Carthamus tinctorius
1.14.19.22 p-chloromercuribenzoate 28% residual activity at 2 mM Carthamus tinctorius

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.22 microsome
-
 Carthamus tinctorius
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.22 oleoyl-[CoA] + ferrocytochrome b5 + O2 + H+ Carthamus tinctorius
-
 linoleoyl-[CoA] + ferricytochrome b5 + H2O
-
 ?
1.14.19.22 oleoyl-[CoA] + ferrocytochrome b5 + O2 + H+ Carthamus tinctorius var High Linoleate
-
 linoleoyl-[CoA] + ferricytochrome b5 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.22 Carthamus tinctorius
-
-
-
1.14.19.22 Carthamus tinctorius var High Linoleate
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.22 cotyledon
-
 Carthamus tinctorius
-
1.14.19.22 seed
-
 Carthamus tinctorius
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.22 oleoyl-[CoA] + ferrocytochrome b5 + O2 + H+
-
 Carthamus tinctorius linoleoyl-[CoA] + ferricytochrome b5 + H2O
-
 ?
1.14.19.22 oleoyl-[CoA] + ferrocytochrome b5 + O2 + H+
-
 Carthamus tinctorius var High Linoleate linoleoyl-[CoA] + ferricytochrome b5 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.22 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine DELTA12-desaturase
-
 Carthamus tinctorius
1.14.19.22 DELTA12-desaturase
-
 Carthamus tinctorius

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.22 cytochrome b5
-
 Carthamus tinctorius
1.14.19.22 NADH dependent on Carthamus tinctorius
1.14.19.22 NADH-cytochrome b5 reductase required for activity Carthamus tinctorius