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Literature summary extracted from
- Mycobacterium tuberculosis S-adenosyl-l-homocysteine hydrolase is negatively regulated by Ser/Thr phosphorylation (2013), Biochem. Biophys. Res. Commun., 430, 858-864.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.13.2.1 | expressed in Escherichia coli BL21(DE3)Star cells | Mycobacterium tuberculosis |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.13.2.1 | 0.0185 | - |
S-adenosyl-L-homocysteine | at pH 7.0 and 37°C | Mycobacterium tuberculosis |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | 50000 | - |
x * 50000, SDS-PAGE | Mycobacterium tuberculosis |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | Mycobacterium tuberculosis | - |
L-homocysteine + adenosine | - |
? | |
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | Mycobacterium tuberculosis H37Rv | - |
L-homocysteine + adenosine | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.13.2.1 | Mycobacterium tuberculosis | - |
- |
- |
| 3.13.2.1 | Mycobacterium tuberculosis H37Rv | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.13.2.1 | phosphoprotein | phosphorylation at Thr2 and Thr221 negatively affects enzymatic activity | Mycobacterium tuberculosis |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.13.2.1 | TALON metal affinity resin column chromatography | Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | - |
Mycobacterium tuberculosis | L-homocysteine + adenosine | - |
? | |
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | - |
Mycobacterium tuberculosis H37Rv | L-homocysteine + adenosine | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.13.2.1 | ? | x * 50000, SDS-PAGE | Mycobacterium tuberculosis |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.13.2.1 | AHCY | - |
Mycobacterium tuberculosis |
| 3.13.2.1 | S-adenosylhomocysteine hydrolase | - |
Mycobacterium tuberculosis |
| 3.13.2.1 | SAHH | - |
Mycobacterium tuberculosis |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.13.2.1 | NAD+ | - |
Mycobacterium tuberculosis | |
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Release 2023.1 (January 2023)
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