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Literature summary extracted from

  • Sun, H.; Samarghandi, A.; Zhang, N.; Yao, Z.; Xiong, M.; Teng, B.B.
    Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor (2012), Arterioscler. Thromb. Vasc. Biol., 32, 1585-1595.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.61 recombinant overexpression of the human enzyme in mouse LDL-receptor null mutant cells, expression and protein profiles, overview. Overexpression of PCSK9 increases plasma ApoB levels in an LDLR-independent fashion Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.61 Homo sapiens Q8NBP7
-
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3.4.21.61 Mus musculus Q80W65
-
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3.4.21.61 Mus musculus C57BL/6 Q80W65
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.61 heart gene expression but no enzyme protein content Mus musculus
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3.4.21.61 hepatocyte primary Mus musculus
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3.4.21.61 kidney gene expression but no enzyme protein content Mus musculus
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3.4.21.61 liver highest gene expression level, enzyme protein content Mus musculus
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3.4.21.61 additional information in LDL-receptor null mutant cells, gene expression and protein profiles, overview Mus musculus
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3.4.21.61 small intestine enzyme protein content Mus musculus
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3.4.21.61 spleen low gene expression level, gene expression but no enzyme protein content Mus musculus
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Synonyms

EC Number Synonyms Comment Organism
3.4.21.61 PCSK9
-
 Homo sapiens
3.4.21.61 PCSK9
-
 Mus musculus
3.4.21.61 proprotein convertase subtilisin/kexin type 9
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 Homo sapiens
3.4.21.61 proprotein convertase subtilisin/kexin type 9
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.21.61 physiological function proprotein convertase subtilisin/kexin type 9 negatively regulates the low-density lipoprotein (LDL) receptor in hepatocytes and plays an important role in controlling circulating levels of LDL-cholesterol. It interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor, resulting in results in increased secretion of apoB-containing lipo­proteins and increased levels of cholesterol and triacylglycerol. PCSK9/apoB interaction results in increased production of apoB, possibly through the inhibition of intracellular apoB degradation via the autophagosome/lysosome pathway. Role for the enzyme in shuttling between apoB and LDLR-receptor Homo sapiens
3.4.21.61 physiological function proprotein convertase subtilisin/kexin type 9 negatively regulates the low-density lipoprotein (LDL) receptor in hepatocytes and plays an important role in controlling circulating levels of LDL-cholesterol. It interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor, resulting in results in increased secretion of apoB-containing lipo­proteins and increased levels of cholesterol and triacylglycerol. PCSK9/apoB interaction results in increased production of apoB, possibly through the inhibition of intracellular apoB degradation via the autophagosome/lysosome pathway. Role for the enzyme in shuttling between apoB and LDLR-receptor Mus musculus