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Literature summary extracted from

  • Kearns, E.V.; Hugly, S.; Somerville, C.R.
    The role of cytochrome b5 in DELTA12 desaturation of oleic acid by microsomes of safflower (Carthamus tinctorius L.) (1991), Arch. Biochem. Biophys., 284, 431-436.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.22 microsome
-
 Carthamus tinctorius
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.22 oleoyl-[CoA] + ferrocytochrome b5 + O2 + H+ Carthamus tinctorius
-
 linoleoyl-[CoA] + ferricytochrome b5 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.22 Carthamus tinctorius
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.22 floret
-
 Carthamus tinctorius
-
1.14.19.22 flower
-
 Carthamus tinctorius
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.22 oleoyl-[CoA] + ferrocytochrome b5 + O2 + H+
-
 Carthamus tinctorius linoleoyl-[CoA] + ferricytochrome b5 + H2O
-
 ?
1.14.19.22 oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ the IgG fraction from ascites fluid inhibits 62% of NADH-dependent cytochrome c reduction in safflower (Carthamus tinctorius L.) microsomes. These antibodies also block desaturation of oleic acid to linoleic acid in lipids of Carthamus tinctorius microsomes by 93%, suggesting that cytochrome b5 is the electron donor for the DELTA12 desaturase Carthamus tinctorius linoleoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.22 DELTA12 desaturase
-
 Carthamus tinctorius

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.22 cytochrome b5
-
 Carthamus tinctorius
1.14.19.22 NAD(P)H
-
 Carthamus tinctorius