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Literature summary extracted from
- Evidence for the role of phosphatidylcholine-specific phospholipase C in sustained hypoxic pulmonary vasoconstriction (2013), Vascul. Pharmacol., 58, 292-298.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.3 | tricyclodecan-9-yl-xanthogenate | i.e. D609, a specific inhibitor, prevents the development of acute hypoxic pulmonary hypertension in rats, and also inhibits pulmonary vasoconstriction induced with a generator of superoxide anions LY83583, but not the one induced with hydrogen peroxide | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.3 | phosphatidylcholine + H2O | Rattus norvegicus | - |
1,2-sn-diacylglycerol + phosphocholine | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.3 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.3 | artery | intrapulmonary arteries | Rattus norvegicus | - |
| 3.1.4.3 | lung | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.3 | phosphatidylcholine + H2O | - |
Rattus norvegicus | 1,2-sn-diacylglycerol + phosphocholine | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.3 | PC-PLC | - |
Rattus norvegicus |
| 3.1.4.3 | phosphatidylcholine-specific phospholipase C | - |
Rattus norvegicus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.1.4.3 | physiological function | the enzyme plays an important role in sustained hypoxic pulmonary vasoconstriction possibly through the activation of protein kinase C-independent mechanism, which may be coupled with phosphocholine release. Phosphocholine induces sustained contraction in isolated intrapulmonary arteries and also transient pulmonary and systemic hypertension if administered intravenously | Rattus norvegicus |
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Release 2023.1 (January 2023)
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