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Literature summary extracted from

  • Okamoto, W.; Sato, T.
    Enzymatic syntheses of unnatural head-to-tail pentacyclic triterpenes by tetraprenyl-beta-curcumene cyclase (2013), Tetrahedron Lett., 54, 6747-6750.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.137 additional information Bacillus subtilis the enzyme forms tetracyclic terpenoid scaffold from tetraprenyl-beta-curcumene in vivo ?
-
 ?
4.2.1.137 additional information Priestia megaterium the enzyme forms tetracyclic terpenoid scaffold from tetraprenyl-beta-curcumene in vivo ?
-
 ?
4.2.1.137 tetraprenyl-beta-curcumene + H2O Bacillus subtilis
-
 baciterpenol A
-
 ?
4.2.1.137 tetraprenyl-beta-curcumene + H2O Priestia megaterium
-
 baciterpenol A
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.137 Bacillus subtilis
-
-
-
4.2.1.137 Priestia megaterium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.137 beta-hexaprene substrate specificity, overview. Enzymatic cyclization of head-to-tail acyclic triterpene beta-hexaprene, a natural product isolated from Bacillus clausii, by tetraprenyl-beta-curcumene cyclase from Bacillus subtilis results in the formation of two unnatural pentacyclic triterpenes. The enzyme can be used to construct the 6/6/6/6/6-fused pentacyclic scaffold in vitro, suggesting that the active site cavity of the enzyme has sufficient space to accommodate this unnatural pentacyclic scaffold Bacillus subtilis ?
-
 ?
4.2.1.137 beta-hexaprene substrate specificity, overview. Enzymatic cyclization of head-to-tail acyclic triterpene beta-hexaprene, a natural product isolated from Bacillus clausii, by tetraprenyl-beta-curcumene cyclase from Bacillus subtilis results in the formation of two unnatural pentacyclic triterpenes. The enzyme can be used to construct the 6/6/6/6/6-fused pentacyclic scaffold in vitro, suggesting that the active site cavity of the enzyme has sufficient space to accommodate this unnatural pentacyclic scaffold Priestia megaterium ?
-
 ?
4.2.1.137 additional information the enzyme forms tetracyclic terpenoid scaffold from tetraprenyl-beta-curcumene in vivo Bacillus subtilis ?
-
 ?
4.2.1.137 additional information the enzyme forms tetracyclic terpenoid scaffold from tetraprenyl-beta-curcumene in vivo Priestia megaterium ?
-
 ?
4.2.1.137 tetraprenyl-beta-curcumene + H2O
-
 Bacillus subtilis baciterpenol A
-
 ?
4.2.1.137 tetraprenyl-beta-curcumene + H2O
-
 Priestia megaterium baciterpenol A
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.137 tetraprenyl-beta-curcumene cyclase
-
 Bacillus subtilis
4.2.1.137 tetraprenyl-beta-curcumene cyclase
-
 Priestia megaterium

General Information

EC Number General Information Comment Organism
4.2.1.137 evolution the enzyme is a sesquarterpene cyclase Bacillus subtilis
4.2.1.137 evolution the enzyme is a sesquarterpene cyclase Priestia megaterium
4.2.1.137 metabolism the enzyme is involved in biosynthetic pathway of sesquarterpenes (C35) and triterpenes (C30), overview Priestia megaterium
4.2.1.137 metabolism the enzyme is involved in biosynthetic pathway of sesquarterpenes (C35), overview Bacillus subtilis