BRENDA - Enzyme Database

The plant non-specific phospholipase C gene family. Novel competitors in lipid signalling

Pokotylo, I.; Pejchar, P.; Potocky, M.; Kocourkova, D.; Krckova, Z.; Ruelland, E.; Kravets, V.; Martinec, J.; Prog. Lipid Res. 52, 62-79 (2013)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
3.1.4.3
expression of the N-terminal domain in Escherichia coli
Clostridium perfringens
3.1.4.3
phylogenetic analysis
Glycine max
3.1.4.3
phylogenetic analysis
Nicotiana tabacum
3.1.4.3
phylogenetic analysis
Oryza sativa
3.1.4.3
phylogenetic analysis
Petunia x hybrida
3.1.4.3
phylogenetic analysis
Physcomitrella patens
3.1.4.3
phylogenetic analysis
Picea sitchensis
3.1.4.3
phylogenetic analysis
Populus trichocarpa
3.1.4.3
phylogenetic analysis
Selaginella moellendorffii
3.1.4.3
phylogenetic analysis
Sorghum bicolor
3.1.4.3
phylogenetic analysis
Vitis vinifera
3.1.4.3
phylogenetic analysis; phylogenetic analysis; phylogenetic analysis; phylogenetic analysis; phylogenetic analysis; phylogenetic analysis
Arabidopsis thaliana
Engineering
EC Number
Amino acid exchange
Commentary
Organism
3.1.4.3
up
the enzyme is induced by 24-epibrassinolide signalling, auxin, cytokinin, phosphate deficiency, abscisic acid, and salt stress. NPC4 does demonstrate a positive response to Botrytis cinerea, Golovinomyces orontii, Pseudomonas syringae and Phytophthora infestans treatment
Arabidopsis thaliana
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.3
additional information
no inhibition by tricyclodecan-9-ylxanthogenate, i.e. D609
Nicotiana tabacum
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609; i.e. D609; i.e. D609; i.e. D609; i.e. D609; i.e. D609
Arabidopsis thaliana
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Bacillus cereus
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Clostridium perfringens
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Glycine max
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Oryza sativa
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Petunia x hybrida
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Physcomitrella patens
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Picea sitchensis
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Populus trichocarpa
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Pseudomonas fluorescens
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Selaginella moellendorffii
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Sorghum bicolor
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Ureaplasma urealyticum
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Vitis vinifera
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.4.3
chloroplast
-
Arabidopsis thaliana
9507
-
3.1.4.3
cytosol
-
Arabidopsis thaliana
5829
-
3.1.4.3
endoplasmic reticulum membrane
;
Arabidopsis thaliana
5789
-
3.1.4.3
extracellular
the enzyme is secreted
Clostridium perfringens
-
-
3.1.4.3
membrane
of stamens and pistils
Petunia x hybrida
16020
-
3.1.4.3
membrane
bound
Ureaplasma urealyticum
16020
-
3.1.4.3
mitochondrion
-
Arabidopsis thaliana
5739
-
3.1.4.3
plasma membrane
-
Nicotiana tabacum
5886
-
3.1.4.3
plasma membrane
-
Arabidopsis thaliana
5886
-
3.1.4.3
tonoplast
-
Arabidopsis thaliana
-
-
3.1.4.3
vacuolar membrane
-
Arabidopsis thaliana
5774
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.4.3
Nal
activates enzyme activity
Ureaplasma urealyticum
3.1.4.3
Zn2+
bound at the N-terminal domain
Clostridium perfringens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.4.3
phosphatidylcholine + H2O
Glycine max
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Pseudomonas fluorescens
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Bacillus cereus
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Sorghum bicolor
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Oryza sativa
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Petunia x hybrida
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Clostridium perfringens
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Ureaplasma urealyticum
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Physcomitrella patens
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Vitis vinifera
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Populus trichocarpa
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Picea sitchensis
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Selaginella moellendorffii
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Arabidopsis thaliana
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylethanolamine + H2O
Arabidopsis thaliana
-
1,2-sn-diacylglycerol + phosphoethanolamine
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.4.3
Arabidopsis thaliana
O81020
NPC2; gene NPC2
-
3.1.4.3
Arabidopsis thaliana
Q8H965
NPC6; gene NPC6
-
3.1.4.3
Arabidopsis thaliana
Q8L7Y9
NPC1; gene NPC1
-
3.1.4.3
Arabidopsis thaliana
Q9S816
NPC5; gene NPC5
-
3.1.4.3
Arabidopsis thaliana
Q9SRQ6
NPC3; gene NPC3
-
3.1.4.3
Arabidopsis thaliana
Q9SRQ7
NPC4; gene NPC4
-
3.1.4.3
Bacillus cereus
-
-
-
3.1.4.3
Clostridium perfringens
-
-
-
3.1.4.3
Glycine max
-
six genes NPC1-6
-
3.1.4.3
Nicotiana tabacum
-
-
-
3.1.4.3
Oryza sativa
-
six genes NPC1-6
-
3.1.4.3
Petunia x hybrida
-
six genes NPC1-6
-
3.1.4.3
Physcomitrella patens
-
single NPC1-like gene
-
3.1.4.3
Picea sitchensis
-
NPC1-, NPC2- and NPC6-like gene, no NPC3-5
-
3.1.4.3
Populus trichocarpa
-
six genes NPC1-6
-
3.1.4.3
Pseudomonas fluorescens
-
-
-
3.1.4.3
Selaginella moellendorffii
-
single NPC1-like gene
-
3.1.4.3
Sorghum bicolor
-
six genes NPC1-6
-
3.1.4.3
Ureaplasma urealyticum
-
-
-
3.1.4.3
Vitis vinifera
-
six genes NPC1-6
-
Purification (Commentary)
EC Number
Commentary
Organism
3.1.4.3
native enzyme
Ureaplasma urealyticum
Reaction
EC Number
Reaction
Commentary
Organism
3.1.4.3
a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphocholine
mode of action of the plant enzyme family of non-specific phospholipases C, overview; mode of action of the plant enzyme family of non-specific phospholipases C, overview; mode of action of the plant enzyme family of non-specific phospholipases C, overview; mode of action of the plant enzyme family of non-specific phospholipases C, overview; mode of action of the plant enzyme family of non-specific phospholipases C, overview; mode of action of the plant enzyme family of non-specific phospholipases C, overview
Arabidopsis thaliana
3.1.4.3
a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphocholine
mode of action of the plant enzyme family of non-specific phospholipases C, overview
Glycine max
3.1.4.3
a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphocholine
mode of action of the plant enzyme family of non-specific phospholipases C, overview
Nicotiana tabacum
3.1.4.3
a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphocholine
mode of action of the plant enzyme family of non-specific phospholipases C, overview
Oryza sativa
3.1.4.3
a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphocholine
mode of action of the plant enzyme family of non-specific phospholipases C, overview
Petunia x hybrida
3.1.4.3
a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphocholine
mode of action of the plant enzyme family of non-specific phospholipases C, overview
Physcomitrella patens
3.1.4.3
a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphocholine
mode of action of the plant enzyme family of non-specific phospholipases C, overview
Picea sitchensis
3.1.4.3
a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphocholine
mode of action of the plant enzyme family of non-specific phospholipases C, overview
Populus trichocarpa
3.1.4.3
a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphocholine
mode of action of the plant enzyme family of non-specific phospholipases C, overview
Selaginella moellendorffii
3.1.4.3
a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphocholine
mode of action of the plant enzyme family of non-specific phospholipases C, overview
Sorghum bicolor
3.1.4.3
a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphocholine
mode of action of the plant enzyme family of non-specific phospholipases C, overview
Vitis vinifera
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.3
cell suspension culture
-
Nicotiana tabacum
-
3.1.4.3
cotyledon
;
Arabidopsis thaliana
-
3.1.4.3
inflorescence
-
Arabidopsis thaliana
-
3.1.4.3
leaf
old
Arabidopsis thaliana
-
3.1.4.3
additional information
tissue distribution, overview; tissue distribution, overview; tissue distribution, overview; tissue distribution, overview; tissue distribution, overview; tissue distribution, overview
Arabidopsis thaliana
-
3.1.4.3
pistil
-
Petunia x hybrida
-
3.1.4.3
pollen
germinating
Arabidopsis thaliana
-
3.1.4.3
root
-
Arabidopsis thaliana
-
3.1.4.3
seedling
higher in seedling hypocotyls and lower in seedling roots
Arabidopsis thaliana
-
3.1.4.3
silique
-
Arabidopsis thaliana
-
3.1.4.3
stamen
-
Petunia x hybrida
-
3.1.4.3
TBY-2 cell
-
Nicotiana tabacum
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.4.3
phosphatidic acid + H2O
-
730853
Arabidopsis thaliana
1,2-sn-diacylglycerol + phosphate
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Glycine max
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Pseudomonas fluorescens
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Bacillus cereus
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Sorghum bicolor
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Oryza sativa
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Petunia x hybrida
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Clostridium perfringens
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Ureaplasma urealyticum
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Physcomitrella patens
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Vitis vinifera
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Populus trichocarpa
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Picea sitchensis
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Selaginella moellendorffii
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Arabidopsis thaliana
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylethanolamine + H2O
-
730853
Arabidopsis thaliana
1,2-sn-diacylglycerol + phosphoethanolamine
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview; the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview; the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview; the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview; the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview; the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Arabidopsis thaliana
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Glycine max
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Nicotiana tabacum
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Oryza sativa
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Petunia x hybrida
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Physcomitrella patens
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Picea sitchensis
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Populus trichocarpa
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Selaginella moellendorffii
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Sorghum bicolor
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Vitis vinifera
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.1.4.3
additional information
-
broad pH optimum
Ureaplasma urealyticum
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.4.3
expression of the N-terminal domain in Escherichia coli
Clostridium perfringens
3.1.4.3
phylogenetic analysis
Arabidopsis thaliana
3.1.4.3
phylogenetic analysis
Glycine max
3.1.4.3
phylogenetic analysis
Nicotiana tabacum
3.1.4.3
phylogenetic analysis
Oryza sativa
3.1.4.3
phylogenetic analysis
Petunia x hybrida
3.1.4.3
phylogenetic analysis
Physcomitrella patens
3.1.4.3
phylogenetic analysis
Picea sitchensis
3.1.4.3
phylogenetic analysis
Populus trichocarpa
3.1.4.3
phylogenetic analysis
Selaginella moellendorffii
3.1.4.3
phylogenetic analysis
Sorghum bicolor
3.1.4.3
phylogenetic analysis
Vitis vinifera
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
3.1.4.3
up
the enzyme is induced by 24-epibrassinolide signalling, auxin, cytokinin, phosphate deficiency, abscisic acid, and salt stress. NPC4 does demonstrate a positive response to Botrytis cinerea, Golovinomyces orontii, Pseudomonas syringae and Phytophthora infestans treatment
Arabidopsis thaliana
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.3
additional information
no inhibition by tricyclodecan-9-ylxanthogenate, i.e. D609
Nicotiana tabacum
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Arabidopsis thaliana
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Bacillus cereus
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Clostridium perfringens
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Glycine max
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Oryza sativa
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Petunia x hybrida
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Physcomitrella patens
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Picea sitchensis
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Populus trichocarpa
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Pseudomonas fluorescens
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Selaginella moellendorffii
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Sorghum bicolor
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Ureaplasma urealyticum
3.1.4.3
tricyclodecan-9-ylxanthogenate
i.e. D609
Vitis vinifera
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.4.3
chloroplast
-
Arabidopsis thaliana
9507
-
3.1.4.3
cytosol
-
Arabidopsis thaliana
5829
-
3.1.4.3
endoplasmic reticulum membrane
-
Arabidopsis thaliana
5789
-
3.1.4.3
extracellular
the enzyme is secreted
Clostridium perfringens
-
-
3.1.4.3
membrane
of stamens and pistils
Petunia x hybrida
16020
-
3.1.4.3
membrane
bound
Ureaplasma urealyticum
16020
-
3.1.4.3
mitochondrion
-
Arabidopsis thaliana
5739
-
3.1.4.3
plasma membrane
-
Arabidopsis thaliana
5886
-
3.1.4.3
plasma membrane
-
Nicotiana tabacum
5886
-
3.1.4.3
tonoplast
-
Arabidopsis thaliana
-
-
3.1.4.3
vacuolar membrane
-
Arabidopsis thaliana
5774
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.4.3
Nal
activates enzyme activity
Ureaplasma urealyticum
3.1.4.3
Zn2+
bound at the N-terminal domain
Clostridium perfringens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.4.3
phosphatidylcholine + H2O
Glycine max
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Pseudomonas fluorescens
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Bacillus cereus
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Sorghum bicolor
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Oryza sativa
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Petunia x hybrida
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Clostridium perfringens
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Ureaplasma urealyticum
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Physcomitrella patens
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Vitis vinifera
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Populus trichocarpa
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Picea sitchensis
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Selaginella moellendorffii
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylcholine + H2O
Arabidopsis thaliana
-
1,2-sn-diacylglycerol + phosphocholine
-
-
?
3.1.4.3
phosphatidylethanolamine + H2O
Arabidopsis thaliana
-
1,2-sn-diacylglycerol + phosphoethanolamine
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.4.3
native enzyme
Ureaplasma urealyticum
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.3
cell suspension culture
-
Nicotiana tabacum
-
3.1.4.3
cotyledon
-
Arabidopsis thaliana
-
3.1.4.3
inflorescence
-
Arabidopsis thaliana
-
3.1.4.3
leaf
old
Arabidopsis thaliana
-
3.1.4.3
leaf
-
Arabidopsis thaliana
-
3.1.4.3
additional information
tissue distribution, overview
Arabidopsis thaliana
-
3.1.4.3
pistil
-
Petunia x hybrida
-
3.1.4.3
pollen
germinating
Arabidopsis thaliana
-
3.1.4.3
root
-
Arabidopsis thaliana
-
3.1.4.3
seedling
higher in seedling hypocotyls and lower in seedling roots
Arabidopsis thaliana
-
3.1.4.3
silique
-
Arabidopsis thaliana
-
3.1.4.3
stamen
-
Petunia x hybrida
-
3.1.4.3
TBY-2 cell
-
Nicotiana tabacum
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.4.3
phosphatidic acid + H2O
-
730853
Arabidopsis thaliana
1,2-sn-diacylglycerol + phosphate
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Glycine max
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Pseudomonas fluorescens
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Bacillus cereus
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Sorghum bicolor
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Oryza sativa
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Petunia x hybrida
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Clostridium perfringens
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Ureaplasma urealyticum
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Physcomitrella patens
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Vitis vinifera
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Populus trichocarpa
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Picea sitchensis
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Selaginella moellendorffii
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylcholine + H2O
-
730853
Arabidopsis thaliana
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
3.1.4.3
phosphatidylethanolamine + H2O
-
730853
Arabidopsis thaliana
1,2-sn-diacylglycerol + phosphoethanolamine
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Arabidopsis thaliana
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Glycine max
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Nicotiana tabacum
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Oryza sativa
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Petunia x hybrida
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Physcomitrella patens
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Picea sitchensis
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Populus trichocarpa
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Selaginella moellendorffii
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Sorghum bicolor
3.1.4.3
More
the enzyme contains a central phosphoesterase domain, a DUF756 domain, a conserved region and a conserved Asp-Arg pair, and some isozymes contain a signal peptide, domain structure, overview
Vitis vinifera
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.1.4.3
additional information
-
broad pH optimum
Ureaplasma urealyticum
Expression
EC Number
Organism
Commentary
Expression
3.1.4.3
Arabidopsis thaliana
the enzyme is induced by 24-epibrassinolide signalling, auxin, and cytokinin. Expression level of NPC3 is increased 14.6fold after 2 h in seedlings subjected to 37°C heat stress. NPC3 does demonstrate a positive response to Botrytis cinerea, Golovinomyces orontii, Pseudomonas syringae and Phytophthora infestans treatment; the enzyme is induced by phosphate deficiency
up
General Information
EC Number
General Information
Commentary
Organism
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C; the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C; the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C; the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C; the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C; the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Arabidopsis thaliana
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Glycine max
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Nicotiana tabacum
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Oryza sativa
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Petunia x hybrida
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Physcomitrella patens
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Picea sitchensis
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Populus trichocarpa
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Selaginella moellendorffii
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Sorghum bicolor
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Vitis vinifera
3.1.4.3
malfunction
npc4 knockout mutants are characterised by a reduced germination rate when sown on media containing 150 mM NaCl. Mutant npc4 plants also have reduced germination and overall viability under salt and drought stress conditions. Unlike wild-type plants, mutants overexpressing NPC4 are characterised by a higher germination level and maintain a greater root length and dry weight under both salt stress and hyperosmosis
Arabidopsis thaliana
3.1.4.3
malfunction
the N-terminal domain of a-toxin retains PC-PLC activity when expressed in Escherichia coli, but lacks haemolytic and sphingomyelinase activities that are supposedly granted by a lipoxygenase-like C-terminal domain
Clostridium perfringens
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview; model of metabolism regulation carried out by plant cell phospholipases, overview; model of metabolism regulation carried out by plant cell phospholipases, overview; model of metabolism regulation carried out by plant cell phospholipases, overview; model of metabolism regulation carried out by plant cell phospholipases, overview; model of metabolism regulation carried out by plant cell phospholipases, overview
Arabidopsis thaliana
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Glycine max
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Nicotiana tabacum
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Oryza sativa
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Petunia x hybrida
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Physcomitrella patens
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Picea sitchensis
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Populus trichocarpa
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Selaginella moellendorffii
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Sorghum bicolor
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Vitis vinifera
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview; sequence comparisons and three-dimensional structure modeling, overview; sequence comparisons and three-dimensional structure modeling, overview; sequence comparisons and three-dimensional structure modeling, overview; sequence comparisons and three-dimensional structure modeling, overview; sequence comparisons and three-dimensional structure modeling, overview
Arabidopsis thaliana
3.1.4.3
additional information
the N-terminal domain contains the phospholipase C active site, which also incorporates zinc ions. The C-terminal C2-like PLAT (polycystin-1, lipoxygenase, alpha-toxin) domain was found to be similar to lipid binding domains in eukaryotes and appears to be responsible for binding membrane phospholipids in a calcium-dependent manner
Clostridium perfringens
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Glycine max
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Nicotiana tabacum
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Oryza sativa
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Petunia x hybrida
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Physcomitrella patens
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Picea sitchensis
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Populus trichocarpa
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Selaginella moellendorffii
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Sorghum bicolor
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Vitis vinifera
3.1.4.3
physiological function
NPC3 might play a rolei in thermotolerance. The enzyme is responsible for lipid conversion during phosphate-limiting conditions. Two articles non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview, inducible expression and putative signalling role; NPC4 participates in triggering plant salt stress responses likely via abscisic acid-dependent mechanisms. The enzyme is responsible for lipid conversion during phosphate-limiting conditions. Two articles non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview, inducible expression and putative signalling role; the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Two articles non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview; the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Two articles non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview; the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Two articles non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview; the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Two articles non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Arabidopsis thaliana
3.1.4.3
physiological function
the enzyme inhibits the formation of cAMP by adenylate cyclase and is involved in the defence mechanism of bacteria to phagocytosis
Bacillus cereus
3.1.4.3
physiological function
the secreted enzyme plays a role in the aggregation of blood platelets and inhibits defensive superoxide generation in human polymorphonuclear leukocytes by interacting with membrane components of NADPH oxidase
Clostridium perfringens
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Glycine max
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Two articles non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Nicotiana tabacum
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Oryza sativa
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Petunia x hybrida
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Physcomitrella patens
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Picea sitchensis
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Populus trichocarpa
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Selaginella moellendorffii
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Sorghum bicolor
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Vitis vinifera
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Arabidopsis thaliana
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Glycine max
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Nicotiana tabacum
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Oryza sativa
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Petunia x hybrida
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Physcomitrella patens
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Picea sitchensis
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Populus trichocarpa
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Selaginella moellendorffii
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Sorghum bicolor
3.1.4.3
evolution
the enzyme belongs to the plant non-specific phospholipase C gene family, phylogenetic tree, overview. The common ancestor of all seed plants already had at least one NPC1-, NPC2- and NPC6-like gene. Non-specific phospholipases C are a distinct type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C
Vitis vinifera
3.1.4.3
malfunction
npc4 knockout mutants are characterised by a reduced germination rate when sown on media containing 150 mM NaCl. Mutant npc4 plants also have reduced germination and overall viability under salt and drought stress conditions. Unlike wild-type plants, mutants overexpressing NPC4 are characterised by a higher germination level and maintain a greater root length and dry weight under both salt stress and hyperosmosis
Arabidopsis thaliana
3.1.4.3
malfunction
the N-terminal domain of a-toxin retains PC-PLC activity when expressed in Escherichia coli, but lacks haemolytic and sphingomyelinase activities that are supposedly granted by a lipoxygenase-like C-terminal domain
Clostridium perfringens
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Arabidopsis thaliana
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Glycine max
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Nicotiana tabacum
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Oryza sativa
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Petunia x hybrida
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Physcomitrella patens
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Picea sitchensis
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Populus trichocarpa
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Selaginella moellendorffii
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Sorghum bicolor
3.1.4.3
metabolism
model of metabolism regulation carried out by plant cell phospholipases, overview
Vitis vinifera
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Arabidopsis thaliana
3.1.4.3
additional information
the N-terminal domain contains the phospholipase C active site, which also incorporates zinc ions. The C-terminal C2-like PLAT (polycystin-1, lipoxygenase, alpha-toxin) domain was found to be similar to lipid binding domains in eukaryotes and appears to be responsible for binding membrane phospholipids in a calcium-dependent manner
Clostridium perfringens
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Glycine max
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Nicotiana tabacum
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Oryza sativa
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Petunia x hybrida
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Physcomitrella patens
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Picea sitchensis
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Populus trichocarpa
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Selaginella moellendorffii
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Sorghum bicolor
3.1.4.3
additional information
sequence comparisons and three-dimensional structure modeling, overview
Vitis vinifera
3.1.4.3
physiological function
NPC4 participates in triggering plant salt stress responses likely via abscisic acid-dependent mechanisms. The enzyme is responsible for lipid conversion during phosphate-limiting conditions. Two articles non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview, inducible expression and putative signalling role
Arabidopsis thaliana
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Two articles non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Arabidopsis thaliana
3.1.4.3
physiological function
NPC3 might play a rolei in thermotolerance. The enzyme is responsible for lipid conversion during phosphate-limiting conditions. Two articles non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview, inducible expression and putative signalling role
Arabidopsis thaliana
3.1.4.3
physiological function
the enzyme inhibits the formation of cAMP by adenylate cyclase and is involved in the defence mechanism of bacteria to phagocytosis
Bacillus cereus
3.1.4.3
physiological function
the secreted enzyme plays a role in the aggregation of blood platelets and inhibits defensive superoxide generation in human polymorphonuclear leukocytes by interacting with membrane components of NADPH oxidase
Clostridium perfringens
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Glycine max
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Two articles non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Nicotiana tabacum
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Oryza sativa
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Petunia x hybrida
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Physcomitrella patens
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Picea sitchensis
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Populus trichocarpa
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Selaginella moellendorffii
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Sorghum bicolor
3.1.4.3
physiological function
the enzyme is responsible for lipid conversion during phosphate-limiting conditions. Non-specific phospholipases C are involved in biotic and abiotic stress responses as well as phytohormone actions. The diacylglycerol produced via the enzymes is postulated to participate in membrane remodelling, general lipid metabolism and cross-talk with other phospholipid signalling systems in plants. Mode of action of the enzyme in lipid metabolism, signal transduction, and membrane remodelling, detailed overview
Vitis vinifera
Expression (protein specific)
EC Number
Organism
Commentary
Expression
3.1.4.3
Arabidopsis thaliana
the enzyme is induced by 24-epibrassinolide signalling, auxin, and cytokinin. Expression level of NPC3 is increased 14.6fold after 2 h in seedlings subjected to 37°C heat stress. NPC3 does demonstrate a positive response to Botrytis cinerea, Golovinomyces orontii, Pseudomonas syringae and Phytophthora infestans treatment
up
3.1.4.3
Arabidopsis thaliana
the enzyme is induced by phosphate deficiency
up