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Literature summary extracted from

  • Poliakov, E.; Gubin, A.N.; Stearn, O.; Li, Y.; Campos, M.M.; Gentleman, S.; Rogozin, I.B.; Redmond, T.M.
    Origin and evolution of retinoid isomerization machinery in vertebrate visual cycle: hint from jawless vertebrates (2012), PLoS ONE, 7, e49975.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.64 DNA and amino acid seuence determination and analysis, phylogenetic analyis and tree, and sequence comparisons, expression in HEK293-F cells Petromyzon marinus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.64 an all-trans-retinyl ester + H2O Petromyzon marinus
-
 11-cis-retinol + a fatty acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.64 no activity in cephalochordata
-
-
-
3.1.1.64 no activity in tunicata
-
-
-
3.1.1.64 Petromyzon marinus L0ATZ0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.64 epithelium
-
 Petromyzon marinus
-
3.1.1.64 retina
-
 Petromyzon marinus
-
3.1.1.64 retinal pigment epithelium
-
 Petromyzon marinus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.64 an all-trans-retinyl ester + H2O
-
 Petromyzon marinus 11-cis-retinol + a fatty acid
-
 ?
3.1.1.64 an all-trans-retinyl ester + H2O the enzyme generates 11-cis-retinol and 13-cis-retinol from all-trans-retinyl ester Petromyzon marinus 11-cis-retinol + a fatty acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.64 isomerohydrolase
-
 Petromyzon marinus
3.1.1.64 Rpe65
-
 Petromyzon marinus

General Information

EC Number General Information Comment Organism
3.1.1.64 evolution the enzyme belongs to the RPE65/BCMO Superfamily. The crucial transition from the typical carotenoid double bond cleavage functionality to the isomerohydrolase functionality (RPE65), coupled with the origin of lecithin:retinol acyltransferase, occurred subsequent to divergence of the more primitive chordates (tunicates, etc.) in the last common ancestor of the jawless and jawed vertebrates Petromyzon marinus