BRENDA - Enzyme Database show

Origin and evolution of retinoid isomerization machinery in vertebrate visual cycle: hint from jawless vertebrates

Poliakov, E.; Gubin, A.N.; Stearn, O.; Li, Y.; Campos, M.M.; Gentleman, S.; Rogozin, I.B.; Redmond, T.M.; PLoS ONE 7, e49975 (2012)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
3.1.1.64
DNA and amino acid seuence determination and analysis, phylogenetic analyis and tree, and sequence comparisons, expression in HEK293-F cells
Petromyzon marinus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.1.64
an all-trans-retinyl ester + H2O
Petromyzon marinus
-
11-cis-retinol + a fatty acid
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.1.64
no activity in cephalochordata
-
-
-
3.1.1.64
no activity in tunicata
-
-
-
3.1.1.64
Petromyzon marinus
L0ATZ0
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.64
epithelium
-
Petromyzon marinus
-
3.1.1.64
retina
-
Petromyzon marinus
-
3.1.1.64
retinal pigment epithelium
-
Petromyzon marinus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.64
an all-trans-retinyl ester + H2O
-
730714
Petromyzon marinus
11-cis-retinol + a fatty acid
-
-
-
?
3.1.1.64
an all-trans-retinyl ester + H2O
the enzyme generates 11-cis-retinol and 13-cis-retinol from all-trans-retinyl ester
730714
Petromyzon marinus
11-cis-retinol + a fatty acid
-
-
-
?
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.1.64
DNA and amino acid seuence determination and analysis, phylogenetic analyis and tree, and sequence comparisons, expression in HEK293-F cells
Petromyzon marinus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.1.64
an all-trans-retinyl ester + H2O
Petromyzon marinus
-
11-cis-retinol + a fatty acid
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.64
epithelium
-
Petromyzon marinus
-
3.1.1.64
retina
-
Petromyzon marinus
-
3.1.1.64
retinal pigment epithelium
-
Petromyzon marinus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.64
an all-trans-retinyl ester + H2O
-
730714
Petromyzon marinus
11-cis-retinol + a fatty acid
-
-
-
?
3.1.1.64
an all-trans-retinyl ester + H2O
the enzyme generates 11-cis-retinol and 13-cis-retinol from all-trans-retinyl ester
730714
Petromyzon marinus
11-cis-retinol + a fatty acid
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
3.1.1.64
evolution
the enzyme belongs to the RPE65/BCMO Superfamily. The crucial transition from the typical carotenoid double bond cleavage functionality to the isomerohydrolase functionality (RPE65), coupled with the origin of lecithin:retinol acyltransferase, occurred subsequent to divergence of the more primitive chordates (tunicates, etc.) in the last common ancestor of the jawless and jawed vertebrates
Petromyzon marinus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.1.1.64
evolution
the enzyme belongs to the RPE65/BCMO Superfamily. The crucial transition from the typical carotenoid double bond cleavage functionality to the isomerohydrolase functionality (RPE65), coupled with the origin of lecithin:retinol acyltransferase, occurred subsequent to divergence of the more primitive chordates (tunicates, etc.) in the last common ancestor of the jawless and jawed vertebrates
Petromyzon marinus