EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.B43 | piceatannol | stimulates EC50: 0.07 mM | Homo sapiens | |
2.3.1.B43 | resveratrol | 0.2 mM resveratrol can stimulate the Sirt5 deacetylase activity against the fluorophore-modified peptide substrate Fluor-de-Lys | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.B43 | expression in Escherichia coli | Homo sapiens |
2.3.1.286 | expression in Escherichia coli | Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.3.1.B43 | crystal structure of Sirt5 in complex with fluor-de-Lys peptide and resveratrol and crystal structure of Sirt5 in complex with fluor-de-Lys peptide and piceatannol | Homo sapiens |
2.3.1.286 | crystal structure of Sirt3 in complex with fluor-de-Lys peptide and resveratrol and crystal structure of Sirt3 in complex with fluor-de-Lys peptide and piceatannol | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.B43 | fisetin | - |
Homo sapiens | |
2.3.1.286 | fisetin | - |
Homo sapiens | |
2.3.1.286 | resveratrol | inhibits deacetylase activity | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.B43 | Homo sapiens | Q9NXA8 | - |
- |
2.3.1.286 | Homo sapiens | Q9NTG7 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.1.B43 | - |
Homo sapiens |
2.3.1.286 | - |
Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.B43 | SIRT5 | - |
Homo sapiens |
2.3.1.286 | SIRT3 | - |
Homo sapiens |