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Literature summary extracted from

  • Gertz, M.; Nguyen, G.T.; Fischer, F.; Suenkel, B.; Schlicker, C.; Fränzel, B.; Tomaschewski, J.; Aladini, F.; Becker, C.; Wolters, D.; Steegborn, C.
    A molecular mechanism for direct sirtuin activation by resveratrol (2012), PLoS One, 7, e49761.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.B43 piceatannol stimulates EC50: 0.07 mM Homo sapiens
2.3.1.B43 resveratrol 0.2 mM resveratrol can stimulate the Sirt5 deacetylase activity against the fluorophore-modified peptide substrate Fluor-de-Lys Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.B43 expression in Escherichia coli Homo sapiens
2.3.1.286 expression in Escherichia coli Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.B43 crystal structure of Sirt5 in complex with fluor-de-Lys peptide and resveratrol and crystal structure of Sirt5 in complex with fluor-de-Lys peptide and piceatannol Homo sapiens
2.3.1.286 crystal structure of Sirt3 in complex with fluor-de-Lys peptide and resveratrol and crystal structure of Sirt3 in complex with fluor-de-Lys peptide and piceatannol Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.B43 fisetin
-
Homo sapiens
2.3.1.286 fisetin
-
Homo sapiens
2.3.1.286 resveratrol inhibits deacetylase activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B43 Homo sapiens Q9NXA8
-
-
2.3.1.286 Homo sapiens Q9NTG7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.B43
-
Homo sapiens
2.3.1.286
-
Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B43 SIRT5
-
Homo sapiens
2.3.1.286 SIRT3
-
Homo sapiens