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Literature summary extracted from

  • Falara, V.; Alba, J.M.; Kant, M.R.; Schuurink, R.C.; Pichersky, E.
    Geranyllinalool synthases in Solanaceae and other angiosperms constitute an ancient branch of diterpene synthases that are involved in the synthesis of defensive compounds (2014), Plant Physiol., 166, 428-441.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.3.144 0.0187
-
 geranylgeranyl diphosphate pH 7.0, temperature not specified in the publication Solanum lycopersicum
4.2.3.144 0.0315
-
 geranylgeranyl diphosphate pH 7.0, temperature not specified in the publication Nicotiana attenuata

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.144 Nicotiana attenuata KJ755868
-
-
4.2.3.144 Solanum lycopersicum KJ755870
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.3.144 flower constitutive expression Nicotiana attenuata
-
4.2.3.144 leaf constitutive expression Nicotiana attenuata
-
4.2.3.144 leaf not expressed under normal growth but induced by alamethicin and methyl jasmonate treatments Solanum lycopersicum
-
4.2.3.144 additional information enzyme is not expressed in any tissue under normal growth Solanum lycopersicum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.144 geranylgeranyl diphosphate + H2O
-
 Nicotiana attenuata (E,E)-geranyllinalool + diphosphate
-
 ?
4.2.3.144 geranylgeranyl diphosphate + H2O enzyme is 55fold more efficient with geranylgeranyl diphosphate than with farnesyl diphosphate. Reaction with farnesyl diphosphate yields nerolidol Solanum lycopersicum (E,E)-geranyllinalool + diphosphate single major product ?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.144 GLS
-
 Solanum lycopersicum
4.2.3.144 GLS
-
 Nicotiana attenuata

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.3.144 6.85
-
 geranylgeranyl diphosphate pH 7.0, temperature not specified in the publication Solanum lycopersicum
4.2.3.144 7.53
-
 geranylgeranyl diphosphate pH 7.0, temperature not specified in the publication Nicotiana attenuata

Expression

EC Number Organism Comment Expression
4.2.3.144 Solanum lycopersicum enzyme is not expressed in any tissue under normal growth but is induced in leaves by alamethicin and methyl jasmonate treatments up
4.2.3.144 Nicotiana attenuata in leaves, expression is induced by methyl jasmonate up

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.2.3.144 0.24
-
 geranylgeranyl diphosphate pH 7.0, temperature not specified in the publication Nicotiana attenuata
4.2.3.144 0.37
-
 geranylgeranyl diphosphate pH 7.0, temperature not specified in the publication Solanum lycopersicum