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Literature summary extracted from

  • Honarmand Ebrahimi, K.; Bill, E.; Hagedoorn, P.L.; Hagen, W.R.
    The catalytic center of ferritin regulates iron storage via Fe(II)-Fe(III) displacement (2012), Nat. Chem. Biol., 8, 941-948.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.16.3.2 E129C the mutant shows severely reduced iron oxidation rate compared to the wild type enzyme Pyrococcus furiosus
1.16.3.2 E129Q the mutant shows severely reduced iron oxidation rate compared to the wild type enzyme Pyrococcus furiosus
1.16.3.2 E129R the mutant shows severely reduced iron oxidation rate compared to the wild type enzyme Pyrococcus furiosus
1.16.3.2 E130H the mutant shows severely reduced iron oxidation rate compared to the wild type enzyme Pyrococcus furiosus
1.16.3.2 E17H the mutant shows severely reduced iron oxidation rate compared to the wild type enzyme Pyrococcus furiosus
1.16.3.2 E50H the mutant shows severely reduced iron oxidation rate compared to the wild type enzyme Pyrococcus furiosus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.16.3.2 Fe2+ the enzyme has three Fe2+ binding events per subunit Pyrococcus furiosus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.16.3.2 Fe(II) + O2 + H2O Pyrococcus furiosus
-
 [FeO(OH)] + H+ + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.16.3.2 Pyrococcus furiosus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.16.3.2 Fe(II) + O2 + H2O
-
 Pyrococcus furiosus [FeO(OH)] + H+ + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.16.3.2 Ftn
-
 Pyrococcus furiosus