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Literature summary extracted from

  • McSorley, F.R.; Wyatt, P.B.; Martinez, A.; DeLong, E.F.; Hove-Jensen, B.; Zechel, D.L.
    PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond (2012), J. Am. Chem. Soc., 134, 8364-8367.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.46 ascorbate required Escherichia coli

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.46 expressed in Escherichia coli BL21(DE3) cells Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.78 EDTA
-
 Escherichia coli
1.13.11.78 Mg2+
-
 Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.78 Ca2+ partial activation compared to Fe2+ Escherichia coli
1.13.11.78 Co2+ partial activation compared to Fe2+ Escherichia coli
1.13.11.78 Cu2+ partial activation compared to Fe2+ Escherichia coli
1.13.11.78 Fe2+ dependent on, contains 1.2 mol of iron per mole of enzyme Escherichia coli
1.13.11.78 Fe3+ partial activation compared to Fe2+ Escherichia coli
1.13.11.78 Mn2+ partial activation compared to Fe2+ Escherichia coli
1.13.11.78 additional information not influenced by Mg2+ Escherichia coli
1.13.11.78 Ni2+ partial activation compared to Fe2+ Escherichia coli
1.13.11.78 Zn2+ partial activation compared to Fe2+ Escherichia coli
1.14.11.46 Fe2+ required Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.78 (2-amino-1-hydroxyethyl)phosphonate + O2 Escherichia coli
-
 glycine + phosphate
-
 ?
1.14.11.46 (2-aminoethyl)phosphonate + 2-oxoglutarate + O2 Escherichia coli
-
 (2-amino-1-hydroxyethyl)phosphonate + succinate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.78 Escherichia coli
-
-
-
1.14.11.46 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.11.46 affinity column chromatography Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.78 (+/-)-(2-amino-1-hydroxyethyl)phosphonate + O2 50% conversion Escherichia coli ?
-
 ?
1.13.11.78 (2-amino-1-hydroxyethyl)phosphonate + O2
-
 Escherichia coli glycine + phosphate
-
 ?
1.14.11.46 (2-aminoethyl)phosphonate + 2-oxoglutarate + O2
-
 Escherichia coli (2-amino-1-hydroxyethyl)phosphonate + succinate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.78 phnZ
-
 Escherichia coli
1.14.11.46 phnY
-
 Escherichia coli