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Literature summary extracted from

  • He, B.; Du, J.; Lin, H.
    Thiosuccinyl peptides as Sirt5-specific inhibitors (2012), J. Am. Chem. Soc., 134, 1922-1925.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.B43 (N6-thiosuccinyl)KSTGGKA
-
 Homo sapiens
2.3.1.B43 Ac-AR(N6-thiosuccinyl)KST-NH2
-
 Homo sapiens
2.3.1.B43 Ac-RR(N6-thiosuccinyl)KRR-NH2
-
 Homo sapiens
2.3.1.B43 AGK2 40% inhibition at 0.1 mM Homo sapiens
2.3.1.B43 AR(N6-thiosuccinyl)KST
-
 Homo sapiens
2.3.1.B43 KQTAR(N6-thiosuccinyl)K
-
 Homo sapiens
2.3.1.B43 KQTAR(N6-thiosuccinyl)KSTGGKA
-
 Homo sapiens
2.3.1.B43 additional information H3K9TAc and sirtinol show no inhibnition at 0.1 mM Homo sapiens
2.3.1.B43 nicotinamide
-
 Homo sapiens
2.3.1.B43 suramin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B43 Homo sapiens Q9NXA8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.B43 NAD+ + KQTAR(N6-succinyl)KSTGGKA
-
 Homo sapiens nicotinamide + KQTARKSTGGKA + 2'-O-succinyl-ADP-ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B43 SIRT5
-
 Homo sapiens
2.3.1.B43 sirtuin 5
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.B43 0.001
-
 pH and temperature not specified in the publication Homo sapiens KQTAR(N6-thiosuccinyl)K
2.3.1.B43 0.001
-
 pH and temperature not specified in the publication Homo sapiens (N6-thiosuccinyl)KSTGGKA
2.3.1.B43 0.005
-
 pH and temperature not specified in the publication Homo sapiens KQTAR(N6-thiosuccinyl)KSTGGKA
2.3.1.B43 0.025
-
 pH and temperature not specified in the publication Homo sapiens suramin
2.3.1.B43 0.025
-
 pH and temperature not specified in the publication Homo sapiens Ac-RR(N6-thiosuccinyl)KRR-NH2
2.3.1.B43 0.03
-
 pH and temperature not specified in the publication Homo sapiens AR(N6-thiosuccinyl)KST
2.3.1.B43 0.04
-
 pH and temperature not specified in the publication Homo sapiens Ac-AR(N6-thiosuccinyl)KST-NH2
2.3.1.B43 0.15
-
 pH and temperature not specified in the publication Homo sapiens nicotinamide