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Literature summary extracted from
- Phosphatidylcholine-specific phospholipase C/heat shock protein 70 (Hsp70)/transcription factor B-cell translocation gene 2 signaling in rat bone marrow stromal cell differentiation to cholinergic neuron-like cells (2012), Int. J. Biochem. Cell Biol., 44, 2253-2260.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.3 | tricyclodecan-9-yl-xanthogenate | i.e. D609, specific inhibitor, does not inhibit sphingomyelin synthase | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.3 | phosphatidylcholine + H2O | Rattus norvegicus | - |
1,2-sn-diacylglycerol + phosphocholine | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.3 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.3 | bone marrow stromal cell | cholinergic neuron-like cells | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.3 | phosphatidylcholine + H2O | - |
Rattus norvegicus | 1,2-sn-diacylglycerol + phosphocholine | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.3 | PC-PLC | - |
Rattus norvegicus |
| 3.1.4.3 | phosphatidylcholine-specific phospholipase C | - |
Rattus norvegicus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.1.4.3 | evolution | the enzyme is a the member of phospholipase C family | Rattus norvegicus |
| 3.1.4.3 | physiological function | the enzyme is involved in PC-PLC-medicated neuronal differentiation of bone marrow stromal cells, and heat shock protein 70 is the pivotal factor by blocking phospholipase C inhibitor D609-induced increase of transcription factor B-cell translocation gene 2 expression and cholinergic neuronal differentiation of bone marrow stromal cells, overview | Rattus norvegicus |
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Release 2023.1 (January 2023)
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