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Literature summary extracted from

  • Wei, Y.; Peng, A.Y.; Wang, B.; Ma, L.; Peng, G.; Du, Y.; Tang, J.
    Synthesis and biological evaluation of phosphorylated flavonoids as potent and selective inhibitors of cholesterol esterase (2014), Eur. J. Med. Chem., 74, 751-758.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.13 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
-
 Sus scrofa
3.1.1.13 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
-
 Sus scrofa
3.1.1.13 2-[3,4-bis[(diethoxyphosphinyl)oxy]phenyl]-4-oxo-4H-1-benzopyran-3,5,7-triyl phosphoric acid hexaethyl ester
-
 Sus scrofa
3.1.1.13 2-[3,4-bis[(diethoxyphosphinyl)oxy]phenyl]-5-hydroxy-4-oxo-4H-1-benzopyran-3,7-diyl phosphoric acid tetraethyl ester
-
 Sus scrofa
3.1.1.13 2-[3,4-bis[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
-
 Sus scrofa
3.1.1.13 2-[3-[(diethoxyphosphinyl)oxy]-4-methoxy-phenyl]-4-oxo-4H-1-benzopyran-5,7-diyl phosphoric acid tetraethyl ester
-
 Sus scrofa
3.1.1.13 2-[4-[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
-
 Sus scrofa
3.1.1.13 2-[[4-(diethoxyphosphinyl)oxy]phenyl]-5-hydroxy-4-oxo-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
-
 Sus scrofa
3.1.1.13 3-[[4-(diethoxyphosphinyl)oxy]phenyl]-4-oxo-4H-1-benzopyran-5,7-diyl phosphoric acid tetraethyl ester
-
 Sus scrofa
3.1.1.13 3-[[4-(diethoxyphosphinyl)oxy]phenyl]-4-oxo-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
-
 Sus scrofa
3.1.1.13 3-[[4-(diethoxyphosphinyl)oxy]phenyl]-5-hydroxy-4-oxo-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
-
 Sus scrofa
3.1.1.13 4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl phosphoric acid hexaethyl ester
-
 Sus scrofa
3.1.1.13 4-oxo-2-phenyl-4H-1-benzopyran-7-yl phosphoric acid dimethyl ester
-
 Sus scrofa
3.1.1.13 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
-
 Sus scrofa
3.1.1.13 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
-
 Sus scrofa
3.1.1.13 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
-
 Sus scrofa
3.1.1.13 5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6,7-diyl phosphoric acid tetraethyl ester
-
 Sus scrofa
3.1.1.13 5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
-
 Sus scrofa
3.1.1.13 5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl phosphoric acid dimethyl ester
-
 Sus scrofa
3.1.1.13 diethyl 4-oxo-2-phenyl-4H-chromen-6-yl phosphate
-
 Sus scrofa
3.1.1.13 diethyl 4-oxo-2-phenyl-4H-chromen-7-yl phosphate
-
 Sus scrofa
3.1.1.13 dimethyl 5-hydroxy-4-oxo-2-phenyl-4H-chromen-4',7-yl phosphate
-
 Sus scrofa
3.1.1.13 additional information not inhibited by 4-oxo-2-phenyl-4H-1-benzopyran-6-yl phosphoric acid dimethyl ester Sus scrofa
3.1.1.13 tetraethyl 4-oxo-2-phenyl-4H-chromene-5,7-diyl bis(phosphate)
-
 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.13 pancreas
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 cholesteryl oleate + H2O
-
 Sus scrofa cholesterol + oleic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 CEase
-
 Sus scrofa
3.1.1.13 cholesterol esterase
-
 Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.13 0.00000072
-
 at pH 7.0 and 25°C Sus scrofa 5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
3.1.1.13 0.00000185
-
 at pH 7.0 and 25°C Sus scrofa 3-[[4-(diethoxyphosphinyl)oxy]phenyl]-5-hydroxy-4-oxo-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
3.1.1.13 0.00000244
-
 at pH 7.0 and 25°C Sus scrofa diethyl 4-oxo-2-phenyl-4H-chromen-7-yl phosphate
3.1.1.13 0.00000376
-
 at pH 7.0 and 25°C Sus scrofa tetraethyl 4-oxo-2-phenyl-4H-chromene-5,7-diyl bis(phosphate)
3.1.1.13 0.00000389
-
 at pH 7.0 and 25°C Sus scrofa 2-[3,4-bis[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
3.1.1.13 0.00000418
-
 at pH 7.0 and 25°C Sus scrofa 2-[[4-(diethoxyphosphinyl)oxy]phenyl]-5-hydroxy-4-oxo-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
3.1.1.13 0.00000462
-
 at pH 7.0 and 25°C Sus scrofa 3-[[4-(diethoxyphosphinyl)oxy]phenyl]-4-oxo-4H-1-benzopyran-5,7-diyl phosphoric acid tetraethyl ester
3.1.1.13 0.0000257
-
 at pH 7.0 and 25°C Sus scrofa 3-[[4-(diethoxyphosphinyl)oxy]phenyl]-4-oxo-4H-1-benzopyran-7-yl phosphoric acid diethyl ester
3.1.1.13 0.0000261
-
 at pH 7.0 and 25°C Sus scrofa 2-[4-[(diethoxyphosphoryl)oxy]phenyl]-4-oxo-4H-chromene-5,7-diyl tetraethyl bis(phosphate)
3.1.1.13 0.0000367
-
 at pH 7.0 and 25°C Sus scrofa 2-[3,4-bis[(diethoxyphosphinyl)oxy]phenyl]-5-hydroxy-4-oxo-4H-1-benzopyran-3,7-diyl phosphoric acid tetraethyl ester
3.1.1.13 0.0000404
-
 at pH 7.0 and 25°C Sus scrofa 2-[3,4-bis[(diethoxyphosphinyl)oxy]phenyl]-4-oxo-4H-1-benzopyran-3,5,7-triyl phosphoric acid hexaethyl ester
3.1.1.13 0.000206
-
 at pH 7.0 and 25°C Sus scrofa 2-[3-[(diethoxyphosphinyl)oxy]-4-methoxy-phenyl]-4-oxo-4H-1-benzopyran-5,7-diyl phosphoric acid tetraethyl ester
3.1.1.13 0.00027
-
 at pH 7.0 and 25°C Sus scrofa dimethyl 5-hydroxy-4-oxo-2-phenyl-4H-chromen-4',7-yl phosphate
3.1.1.13 0.00039
-
 at pH 7.0 and 25°C Sus scrofa diethyl 4-oxo-2-phenyl-4H-chromen-6-yl phosphate
3.1.1.13 0.00069
-
 at pH 7.0 and 25°C Sus scrofa 4-oxo-2-phenyl-4H-1-benzopyran-7-yl phosphoric acid dimethyl ester
3.1.1.13 0.00134
-
 at pH 7.0 and 25°C Sus scrofa 4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl phosphoric acid hexaethyl ester
3.1.1.13 0.00472
-
 at pH 7.0 and 25°C Sus scrofa 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
3.1.1.13 0.0123
-
 at pH 7.0 and 25°C Sus scrofa 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
3.1.1.13 0.0209
-
 at pH 7.0 and 25°C Sus scrofa 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
3.1.1.13 0.0281
-
 at pH 7.0 and 25°C Sus scrofa 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
3.1.1.13 0.0357
-
 at pH 7.0 and 25°C Sus scrofa 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
3.1.1.13 0.17
-
 at pH 7.0 and 25°C Sus scrofa 5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl phosphoric acid dimethyl ester
3.1.1.13 0.43
-
 at pH 7.0 and 25°C Sus scrofa 5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6,7-diyl phosphoric acid tetraethyl ester