EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.B41 | additional information | the enzyme is unaffected by the activators isonicotinamide and resveratrol | Plasmodium falciparum |
EC Number | Application | Comment | Organism |
---|---|---|---|
2.3.1.B41 | medicine | PfSir2A inhibitors may have therapeutic value in malaria treatment | Plasmodium falciparum |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.B41 | expressed in Escherichia coli with a C-terminal His6 tag and an N-terminal T7 tag | Plasmodium falciparum |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.B41 | additional information | splitomicin and sirtinol fail to inhibit PfSir2 | Plasmodium falciparum | |
2.3.1.B41 | nicotinamide | inhibits the deacetylation of native histones much more effectively than deacetylation of a synthetic substrate | Plasmodium falciparum |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.3.1.B41 | 30000 | - |
x * 30000, SDS-PAGE | Plasmodium falciparum |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.B41 | Plasmodium falciparum | Q8IE47 | - |
- |
2.3.1.B41 | Plasmodium falciparum isolate 3D7 | Q8IE47 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.1.B41 | - |
Plasmodium falciparum |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.B41 | NAD+ + [histone H3]-N6-acetyl-L-lysine | - |
Plasmodium falciparum | nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP-ribose | - |
? | |
2.3.1.B41 | NAD+ + [histone H3]-N6-acetyl-L-lysine | - |
Plasmodium falciparum isolate 3D7 | nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP-ribose | - |
? | |
2.3.1.B41 | NAD+ + [histone H4]-N6-acetyl-L-lysine | - |
Plasmodium falciparum | nicotinamide + [histone H4]-L-lysine + 2'-O-acetyl-ADP-ribose | - |
? | |
2.3.1.B41 | NAD+ + [histone H4]-N6-acetyl-L-lysine | - |
Plasmodium falciparum isolate 3D7 | nicotinamide + [histone H4]-L-lysine + 2'-O-acetyl-ADP-ribose | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.1.B41 | ? | x * 30000, SDS-PAGE | Plasmodium falciparum |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.B41 | Sir2A | - |
Plasmodium falciparum |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.1.B41 | 37 | - |
assay at | Plasmodium falciparum |