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Literature summary extracted from

  • Ayuk-Takem, L.; Amissah, F.; Aguilar, B.J.; Lamango, N.S.
    Inhibition of polyisoprenylated methylated protein methyl esterase by synthetic musks induces cell degeneration (2014), Environ. Toxicol., 29, 466-477.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.1 Galaxolide synthetic fragrance Galaxolide induces human cancer cell degeneration with a EC50 value of 0.026 mM in neuroblastoma SH-SY5Y cells and 0.058 mM in lung cancer A549 cells Homo sapiens
3.1.1.1 Galaxolide synthetic fragrance Galaxolide Sus scrofa
3.1.1.1 additional information inhibitor docking study, overview Homo sapiens
3.1.1.1 additional information inhibitor docking study, overview Sus scrofa
3.1.1.1 Tonalide synthetic fragrance Tonalide induces human cancer cell degeneration with a EC50 value of 0.098 mM in neuroblastoma SH-SY5Y cells and 0.014 mM in lung cancer A549 cells Homo sapiens
3.1.1.1 Tonalide synthetic fragrance Tonalide Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.1 Homo sapiens
-
-
-
3.1.1.1 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.1 A-549 cell
-
 Homo sapiens
-
3.1.1.1 liver
-
 Sus scrofa
-
3.1.1.1 lung cancer cell
-
 Homo sapiens
-
3.1.1.1 neuroblastoma cell
-
 Homo sapiens
-
3.1.1.1 SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.1 N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O specific enzyme substrate Homo sapiens ?
-
 ?
3.1.1.1 N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O specific enzyme substrate Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.1 PMPMEase
-
 Homo sapiens
3.1.1.1 PMPMEase
-
 Sus scrofa
3.1.1.1 polyisoprenylated methylated protein methyl esterase
-
 Homo sapiens
3.1.1.1 polyisoprenylated methylated protein methyl esterase
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.1 37
-
 assay at Homo sapiens
3.1.1.1 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.1 7.4
-
 assay at Homo sapiens
3.1.1.1 7.4
-
 assay at Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.1 0.011
-
 Galaxolide pH 7.4, 37°C Sus scrofa
3.1.1.1 0.014
-
 Tonalide pH 7.4, 37°C Sus scrofa

General Information

EC Number General Information Comment Organism
3.1.1.1 malfunction neurotoxicity of synthetic fragrances may be associated with their inhibition of the enzyme Homo sapiens