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Literature summary extracted from

  • Cheng, J.; Karri, S.; Grauffel, C.; Wang, F.; Reuter, N.; Roberts, M.F.; Wintrode, P.L.; Gershenson, A.
    Does changing the predicted dynamics of a phospholipase C alter activity and membrane binding? (2013), Biophys. J., 104, 185-195.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.13 phosphatidylcholine
-
 Bacillus thuringiensis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.13 expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells Bacillus thuringiensis

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.13 P245Y the mutant shows reduced activity and membrane affinity Bacillus thuringiensis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.13 membrane
-
 Bacillus thuringiensis 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.13 1-phosphatidyl-1D-myo-inositol Bacillus thuringiensis
-
 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?
4.6.1.13 1-phosphatidyl-1D-myo-inositol Bacillus thuringiensis N168C
-
 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.13 Bacillus thuringiensis P08954
-
-
4.6.1.13 Bacillus thuringiensis N168C P08954
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.13 1-phosphatidyl-1D-myo-inositol
-
 Bacillus thuringiensis 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?
4.6.1.13 1-phosphatidyl-1D-myo-inositol
-
 Bacillus thuringiensis N168C 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.13 phosphatidylinositol-specific phospholipase C
-
 Bacillus thuringiensis
4.6.1.13 PI-PLC
-
 Bacillus thuringiensis