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Literature summary extracted from

  • Muscia, G.C.; Hautmann, S.; Buldain, G.Y.; Asis, S.E.; Guetschow, M.
    Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase (2014), Bioorg. Med. Chem. Lett., 24, 1545-1549.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.13 2-(1H-indol-3-yl)-6-nitro-4-phenylquinoline competitive mixed-type inhibitor Sus scrofa
3.1.1.13 2-(3-bromophenyl)-6-chloro-4-phenylquinoline
-
 Sus scrofa
3.1.1.13 2-(3-bromophenyl)-6-nitro-4-phenylquinoline
-
 Sus scrofa
3.1.1.13 2-(4-hydroxyphenyl)-6-nitro-4-phenylquinoline
-
 Sus scrofa
3.1.1.13 2-(4-methylphenyl)-6-nitro-4-phenylquinoline
-
 Sus scrofa
3.1.1.13 6-chloro-2,4-diphenylquinoline
-
 Sus scrofa
3.1.1.13 6-chloro-2-(1H-indol-3-yl)-4-phenylquinoline
-
 Sus scrofa
3.1.1.13 6-chloro-2-(4-hydroxyphenyl)-4-phenylquinoline
-
 Sus scrofa
3.1.1.13 6-chloro-2-(4-methoxyphenyl)-4-phenylquinoline
-
 Sus scrofa
3.1.1.13 6-chloro-2-(4-methylphenyl)-4-phenylquinoline
-
 Sus scrofa
3.1.1.13 6-nitro-2,4-diphenylquinoline
-
 Sus scrofa
3.1.1.13 additional information not inhibited by 2-(4-methoxyphenyl)-6-nitro-4-phenylquinoline Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Sus scrofa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 cholesteryl acetate + H2O
-
 Sus scrofa cholesterol + acetate
-
 ?
3.1.1.13 cholesteryl oleate + H2O
-
 Sus scrofa cholesterol + oleic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 CEase
-
 Sus scrofa
3.1.1.13 cholesterol esterase
-
 Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.13 0.00133
-
 at pH 7.0 and 25°C Sus scrofa 6-chloro-2-(1H-indol-3-yl)-4-phenylquinoline
3.1.1.13 0.00198
-
 at pH 7.0 and 25°C Sus scrofa 2-(1H-indol-3-yl)-6-nitro-4-phenylquinoline
3.1.1.13 0.00198
-
 at pH 7.0 and 25°C Sus scrofa 2-(3-bromophenyl)-6-nitro-4-phenylquinoline
3.1.1.13 0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 6-chloro-2,4-diphenylquinoline
3.1.1.13 0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 6-chloro-2-(4-methylphenyl)-4-phenylquinoline
3.1.1.13 0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 6-chloro-2-(4-hydroxyphenyl)-4-phenylquinoline
3.1.1.13 0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 6-chloro-2-(4-methoxyphenyl)-4-phenylquinoline
3.1.1.13 0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 2-(3-bromophenyl)-6-chloro-4-phenylquinoline
3.1.1.13 0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 6-nitro-2,4-diphenylquinoline
3.1.1.13 0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 2-(4-methylphenyl)-6-nitro-4-phenylquinoline
3.1.1.13 0.02
-
 IC50 above or equal 0.02 mM, at pH 7.0 and 25°C Sus scrofa 2-(4-hydroxyphenyl)-6-nitro-4-phenylquinoline